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Tablet of Ximenia Americana L. Developed from Mucoadhesive Polymers for Future Use in Oral Treatment of Fungal Infections

1
Laboratório de Desenvolvimento e Ensaios de Medicamentos, Centro de Ciências Biológicas e da Saúde, Universidade Estadual da Paraíba, R. Baraúnas, 351, Cidade Universitária, 58429-500, Campina Grande, Paraíba, Brasil
2
Centro de Tecnologia e Desenvolvimento Regional, Universidade Federal da Paraíba, Av. dos Escoteiros, s/n, Mangabeira VII, 58055-000, João Pessoa, Paraíba, Brasil
3
Laboratório de Química Analítica e Quimiometria, Centro de Ciências Biológicas e da Saúde, Universidade Estadual da Paraíba, R. Baraúnas, 351, Cidade Universitária, 58429-500, Campina Grande, Paraíba, Brasil
*
Authors to whom correspondence should be addressed.
Polymers 2019, 11(2), 379; https://doi.org/10.3390/polym11020379
Received: 28 December 2018 / Revised: 15 February 2019 / Accepted: 17 February 2019 / Published: 20 February 2019
(This article belongs to the Special Issue Biomedical Polymer Materials)
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Abstract

The use of biocompatible polymers such as Hydroxypropylmethylcellulose (HPMC), Hydroxyethylcellulose (HEC), Carboxymethylcellulose (CMC), and Carbopol in solid formulations results in mucoadhesive systems capable of promoting the prolonged and localized release of Active Pharmaceutical Ingredients (APIs). This strategy represents a technological innovation that can be applied to improving the treatment of oral infections, such as oral candidiasis. Therefore, the aim of this study was to develop a tablet of Ximenia americana L. from mucoadhesive polymers for use in the treatment of oral candidiasis. An X. americana extract (MIC of 125 μg·mL−1) was obtained by turbolysis at 50% of ethanol, a level that demonstrated activity against Candida albicans. Differential Thermal Analysis and Fourier Transform Infrared Spectroscopy techniques allowed the choice of HPMC as a mucoadhesive agent, besides polyvinylpyrrolidone, magnesium stearate, and mannitol to integrate the formulation of X. americana. These excipients were granulated with an ethanolic solution 70% v/v at PVP 5%, and a mucoadhesive tablet was obtained by compression. Finally, mucoadhesive strength was evaluated, and the results demonstrated good mucoadhesive forces in mucin disk and pig buccal mucosa. Therefore, the study allowed a new alternative to be developed for the treatment of buccal candidiasis, one which overcomes the inconveniences of common treatments, costs little, and facilitates patients’ adhesion. View Full-Text
Keywords: Ximenia americana L.; compatibility; hydrophilic polymers; mucoadhesive tablets Ximenia americana L.; compatibility; hydrophilic polymers; mucoadhesive tablets
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Almeida, L.; Oshiro Júnior, J.A.; Silva, M.; Nóbrega, F.; Andrade, J.; Santos, W.; Ribeiro, A.; Conceição, M.; Veras, G.; Medeiros, A.C. Tablet of Ximenia Americana L. Developed from Mucoadhesive Polymers for Future Use in Oral Treatment of Fungal Infections. Polymers 2019, 11, 379.

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