Next Article in Journal
Effect of Intercalation Structure of Organo-Modified Montmorillonite/Polylactic Acid on Wheat Straw Fiber/Polylactic Acid Composites
Next Article in Special Issue
Thinking Green: Sustainable Polymers from Renewable Resources
Previous Article in Journal
Punching Shear Behavior of Two-Way Concrete Slabs Reinforced with Glass-Fiber-Reinforced Polymer (GFRP) Bars
Previous Article in Special Issue
Furanoate-Based Nanocomposites: A Case Study Using Poly(Butylene 2,5-Furanoate) and Poly(Butylene 2,5-Furanoate)-co-(Butylene Diglycolate) and Bacterial Cellulose
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessArticle
Polymers 2018, 10(8), 895;

Dual Drug Delivery of Sorafenib and Doxorubicin from PLGA and PEG-PLGA Polymeric Nanoparticles

Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudósok körútja 2., H-1117 Budapest, Hungary
Research Institute of Biomolecular and Chemical Engineering, University of Pannonia, Egyetem u. 10, H-8200 Veszprém, Hungary
Author to whom correspondence should be addressed.
Received: 9 July 2018 / Revised: 3 August 2018 / Accepted: 6 August 2018 / Published: 9 August 2018
(This article belongs to the Special Issue Polymers from Renewable Resources)
Full-Text   |   PDF [2796 KB, uploaded 9 August 2018]   |  


Combinatorial drug delivery is a way of advanced cancer treatment that at present represents a challenge for researchers. Here, we report the efficient entrapment of two clinically used single-agent drugs, doxorubicin and sorafenib, against hepatocellular carcinoma. Biocompatible and biodegradable polymeric nanoparticles provide a promising approach for controlled drug release. In this study, doxorubicin and sorafenib with completely different chemical characteristics were simultaneously entrapped by the same polymeric carrier, namely poly(d,l-lactide-co-glycolide) (PLGA) and polyethylene glycol-poly(d,l-lactide-co-glycolide) (PEG-PLGA), respectively, using the double emulsion solvent evaporation method. The typical mean diameters of the nanopharmaceuticals were 142 and 177 nm, respectively. The PLGA and PEG-PLGA polymers encapsulated doxorubicin with efficiencies of 52% and 69%, respectively, while these values for sorafenib were 55% and 88%, respectively. Sustained drug delivery under biorelevant conditions was found for doxorubicin, while sorafenib was released quickly from the PLGA-doxorubicin-sorafenib and PEG-PLGA-doxorubicin-sorafenib nanotherapeutics. View Full-Text
Keywords: sorafenib; doxorubicin; polymeric nanoparticles; drug delivery sorafenib; doxorubicin; polymeric nanoparticles; drug delivery

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
Printed Edition Available!
A printed edition of this Special Issue is available here.

Share & Cite This Article

MDPI and ACS Style

Babos, G.; Biró, E.; Meiczinger, M.; Feczkó, T. Dual Drug Delivery of Sorafenib and Doxorubicin from PLGA and PEG-PLGA Polymeric Nanoparticles. Polymers 2018, 10, 895.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Polymers EISSN 2073-4360 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top