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Polymers 2018, 10(8), 851; https://doi.org/10.3390/polym10080851

A Methodologic Approach for the Selection of Bio-Resorbable Polymers in the Development of Medical Devices: The Case of Poly(l-lactide-co-ε-caprolactone)

1
Institute for Chemical and Bioengineering, Department of Chemistry and Applied Bioscience ETH Zurich, Vladimir-Prelog-Weg 1-5/10, 8093 Zürich, Switzerland
2
Industrie Biomediche Insubri SA (IBI), Via Cantonale 67, 6805 Mezzovico-Vira, Switzerland
3
Biomaterials Laboratory, Institute for Mechanical Engineering and Materials Technology, SUPSI—University of Applied Sciences and Arts of Southern Switzerland, Via Cantonale 2C, Galleria 2, 6928 Manno, Switzerland
4
Department of Chemistry, Materials and Chemical Engineering “G. Natta”, Politecnico di Milano, 20100 Milan, Italy
*
Authors to whom correspondence should be addressed.
Received: 30 June 2018 / Revised: 23 July 2018 / Accepted: 31 July 2018 / Published: 1 August 2018
(This article belongs to the Special Issue Polymers: Design, Function and Application)
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Abstract

In the last decades bioresorbable and biodegradable polymers have gained a very good reputation both in research and in industry thanks to their unique characteristics. They are able to ensure high performance and biocompatibility, at the same time avoiding post-healing surgical interventions for device removal. In the medical device industry, it is widely known that product formulation and manufacturing need to follow specific procedures in order to ensure both the proper mechanical properties and desired degradation profile. Moreover, the sterilization method is crucial and its impact on physical properties is generally underestimated. In this work we focused our attention on the effect of different terminal sterilization methods on two commercially available poly(l-lactide-co-ε-caprolactone) with equivalent chemical composition (70% PLA and 30% PCL) and relatively similar initial molecular weights, but different chain arrangements and crystallinity. Results obtained show that crystallinity plays a key role in helping preserve the narrow distribution of chains and, as a consequence, defined physical properties. These statements can be used as guidelines for a better choice of the most adequate biodegradable polymers in the production of resorbable medical devices. View Full-Text
Keywords: electron beam; ethylene oxide; medical devices; polymers; sterilization electron beam; ethylene oxide; medical devices; polymers; sterilization
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Cingolani, A.; Casalini, T.; Caimi, S.; Klaue, A.; Sponchioni, M.; Rossi, F.; Perale, G. A Methodologic Approach for the Selection of Bio-Resorbable Polymers in the Development of Medical Devices: The Case of Poly(l-lactide-co-ε-caprolactone). Polymers 2018, 10, 851.

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