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Article

A Facile, One-Pot, Surfactant-Free Nanoprecipitation Method for the Preparation of Nanogels from Polyglycerol–Drug Conjugates that Can Be Freely Assembled for Combination Therapy Applications

Freie Universität Berlin, Institut für Chemie und Biochemie, Takustrasse 3, 14195 Berlin, Germany
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Polymers 2018, 10(4), 398; https://doi.org/10.3390/polym10040398
Received: 15 February 2018 / Revised: 22 March 2018 / Accepted: 27 March 2018 / Published: 3 April 2018
(This article belongs to the Special Issue Polymers for Therapy and Diagnostics)
A well-established strategy to treat drug resistance is the use of multiple therapeutics. Polymer-based drug delivery systems (DDS) can facilitate a simultaneous delivery of two or more drugs. In this study, we developed and synthesized a dendritic polyglycerol (PG) nanogel (NG) system that allows for free combination of different fixed ratios of active compound conjugates within a single NG particle. As a proof of concept, we synthesized NGs bearing the chemotherapeutic agent doxorubicin (DOX) and paclitaxel (PTX) in different ratios, as well as conjugated dye molecules. Our combination PG NGs were formed by simply mixing PG–drug/dye conjugates bearing free thiol groups with PG-acrylate in an inverse surfactant-free nanoprecipitation method. With this method we obtained PG-NGs in the size range of 110–165 nm with low polydispersity indices. Solubility of hydrophobic PTX was improved without the need for additional solubilizing agents such as polyethylene glycol (PEG). Interestingly, we found that our NGs made from PG-DOX conjugates have a high quenching efficiency for DOX, which could be interesting for theranostic purposes. View Full-Text
Keywords: combination therapy; prodrug; polyglycerol; nanogel; doxorubicin; paclitaxel combination therapy; prodrug; polyglycerol; nanogel; doxorubicin; paclitaxel
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MDPI and ACS Style

Vossen, L.I.; Wedepohl, S.; Calderón, M. A Facile, One-Pot, Surfactant-Free Nanoprecipitation Method for the Preparation of Nanogels from Polyglycerol–Drug Conjugates that Can Be Freely Assembled for Combination Therapy Applications. Polymers 2018, 10, 398. https://doi.org/10.3390/polym10040398

AMA Style

Vossen LI, Wedepohl S, Calderón M. A Facile, One-Pot, Surfactant-Free Nanoprecipitation Method for the Preparation of Nanogels from Polyglycerol–Drug Conjugates that Can Be Freely Assembled for Combination Therapy Applications. Polymers. 2018; 10(4):398. https://doi.org/10.3390/polym10040398

Chicago/Turabian Style

Vossen, Laura I., Stefanie Wedepohl, and Marcelo Calderón. 2018. "A Facile, One-Pot, Surfactant-Free Nanoprecipitation Method for the Preparation of Nanogels from Polyglycerol–Drug Conjugates that Can Be Freely Assembled for Combination Therapy Applications" Polymers 10, no. 4: 398. https://doi.org/10.3390/polym10040398

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