Next Article in Journal
Structural Transformations in Crystals Induced by Radiation and Pressure. Part 7. Molecular and Crystal Geometries as Factors Deciding about Photochemical Reactivity under Ambient and High Pressures
Previous Article in Journal
Heavily Boron Doped Diamond Powder: Synthesis and Rietveld Refinement
Article

Cryochemically Obtained Nanoforms of Antimicrobial Drug Substance Dioxidine and Their Physico-chemical and Structural Properties

1
Department of Chemistry, M.V. Lomonosov Moscow State University, Leninskie Gori build. 1/3, Moscow 119991, Russia
2
Bauman Moscow State Technical University, 2nd Bauman Str. 5, Moscow 105905, Russia
3
European Synchrotron Radiation Faculty, B.P. 220, 38043 Grenoble CEDEX, France
4
Frumkin Institute of Physical Chemistry and Electrochemistry RAS, Leninskii prospect 31, Moscow 119071, Russia
*
Author to whom correspondence should be addressed.
Crystals 2018, 8(7), 298; https://doi.org/10.3390/cryst8070298
Received: 1 June 2018 / Revised: 3 July 2018 / Accepted: 17 July 2018 / Published: 19 July 2018
(This article belongs to the Section Crystal Engineering)
Nanoforms of the antimicrobial drug substance 2,3-bis-(hydroxymethyl) quinoxaline-N,N′-dioxide with particles sizes between 50 and 300 nm were obtained by cryochemical modification of the initial pharmaceutical substance using a freeze-drying technique and were characterized by different physicochemical methods (FTIR, UV-Vis, 1H-NMR, DSC, TG and X-ray diffraction) and transmission electron microscopy (TEM). The data obtained from FTIR- and UV–Vis-spectroscopy confirmed the unaltered chemical structure of dioxidine molecules due to the cryochemical modification method. At the same time, X-ray diffraction and thermal analysis data show the change of the crystal structure compared to the parameters of the initial pharmaceutical dioxidine substance. A higher dissolution rate was revealed for cryomodified dioxidine nanoforms. The existence of three polymorphic crystal phases was established for cryomodified dioxidine samples possessed by some thermal activation processes: two anhydrous polymorphic phases, triclinic (T) and monoclinic (M), and one hydrated form (H). View Full-Text
Keywords: drug nanoforms; cryochemical synthesis; polymorphism; antimicrobial substances; dioxidine drug nanoforms; cryochemical synthesis; polymorphism; antimicrobial substances; dioxidine
Show Figures

Graphical abstract

MDPI and ACS Style

Shabatina, T.I.; Vernaya, O.I.; Shabatin, V.P.; Evseeva, I.V.; Melnikov, M.Y.; Fitch, A.N.; Chernyshev, V.V. Cryochemically Obtained Nanoforms of Antimicrobial Drug Substance Dioxidine and Their Physico-chemical and Structural Properties. Crystals 2018, 8, 298. https://doi.org/10.3390/cryst8070298

AMA Style

Shabatina TI, Vernaya OI, Shabatin VP, Evseeva IV, Melnikov MY, Fitch AN, Chernyshev VV. Cryochemically Obtained Nanoforms of Antimicrobial Drug Substance Dioxidine and Their Physico-chemical and Structural Properties. Crystals. 2018; 8(7):298. https://doi.org/10.3390/cryst8070298

Chicago/Turabian Style

Shabatina, Tatyana I., Olga I. Vernaya, Vladimir P. Shabatin, Iuliia V. Evseeva, Michail Y. Melnikov, Andrew N. Fitch, and Vladimir V. Chernyshev 2018. "Cryochemically Obtained Nanoforms of Antimicrobial Drug Substance Dioxidine and Their Physico-chemical and Structural Properties" Crystals 8, no. 7: 298. https://doi.org/10.3390/cryst8070298

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop