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Venom Peptides as a Rich Source of Cav2.2 Channel Blockers

Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, 4072, Australia
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Toxins 2013, 5(2), 286-314; https://doi.org/10.3390/toxins5020286
Received: 2 November 2012 / Revised: 7 January 2013 / Accepted: 25 January 2013 / Published: 4 February 2013
(This article belongs to the Special Issue Animal Toxins Targeting Ion Channels Involved in Pain)
Cav2.2 is a calcium channel subtype localized at nerve terminals, including nociceptive fibers, where it initiates neurotransmitter release. Cav2.2 is an important contributor to synaptic transmission in ascending pain pathways, and is up-regulated in the spinal cord in chronic pain states along with the auxiliary α2δ1 subunit. It is therefore not surprising that toxins that inhibit Cav2.2 are analgesic. Venomous animals, such as cone snails, spiders, snakes, assassin bugs, centipedes and scorpions are rich sources of remarkably potent and selective Cav2.2 inhibitors. However, side effects in humans currently limit their clinical use. Here we review Cav2.2 inhibitors from venoms and their potential as drug leads. View Full-Text
Keywords: Cav2.2; voltage-gated calcium channels; nociception; neurotransmitter; ω-conotoxins; venom peptides Cav2.2; voltage-gated calcium channels; nociception; neurotransmitter; ω-conotoxins; venom peptides
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MDPI and ACS Style

Sousa, S.R.; Vetter, I.; Lewis, R.J. Venom Peptides as a Rich Source of Cav2.2 Channel Blockers. Toxins 2013, 5, 286-314. https://doi.org/10.3390/toxins5020286

AMA Style

Sousa SR, Vetter I, Lewis RJ. Venom Peptides as a Rich Source of Cav2.2 Channel Blockers. Toxins. 2013; 5(2):286-314. https://doi.org/10.3390/toxins5020286

Chicago/Turabian Style

Sousa, Silmara R., Irina Vetter, and Richard J. Lewis 2013. "Venom Peptides as a Rich Source of Cav2.2 Channel Blockers" Toxins 5, no. 2: 286-314. https://doi.org/10.3390/toxins5020286

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