Predictive Factors for the Successful Outcome of Urethral Sphincter Injections of Botulinum Toxin A for Non-Neurogenic Dysfunctional Voiding in Women
Abstract
1. Introduction
2. Results
3. Discussion
4. Conclusions
5. Methods
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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VUDS Parameter | Baseline | Post-BoNT-A | p-Value |
---|---|---|---|
FSF (mL) | 124.1 ± 66.6 | 132.9 ± 59.9 | 0.389 |
FS (mL) | 200.8 ± 90.2 | 212.9 ± 95.8 | 0.334 |
US (mL) | 241.2 ± 106.1 | 241.2 ± 105.8 | 0.998 |
Pdet (cmH2O) | 49.4 ± 27.8 | 44.3 ± 30.9 | 0.167 |
Qmax (mL/s) | 9.2 ± 6.9 | 12.3 ± 7.8 | <0.001 |
Volume (mL) | 144.8 ± 106.9 | 209.0 ± 121.0 | <0.001 |
PVR (ml) | 132.9 ± 155.6 | 100.9 ± 109.3 | 0.052 |
VE | 0.58 ± 0.30 | 0.69 ± 0.27 | 0.002 |
BOOI | 32.5 ± 31.9 | 26.6 ± 33.7 | 0.104 |
BCI | 91.7 ± 36.2 | 88.7 ± 43.0 | 0.605 |
Failure (n = 39) | Successful (n = 27) | p-Value | |
---|---|---|---|
BoNT-A injection(s) | |||
Single injection | 18 (46.2%) | 15 (55.6%) | 0.453 |
Repeat injections | 21 (53.8%) | 12 (44.4%) | |
Comorbidities | |||
Hypertension | 13 (33.3%) | 14 (51.9) | 0.132 |
Diabetes mellitus | 8 (20.5%) | 7 (25.9%) | 0.606 |
Coronary artery disease | 4 (10.3%) | 2 (7.4%) | 1.000 |
Chronic kidney disease | 2 (5.1%) | 2 (7.4%) | 1.000 |
Cerebrovascular disease | 1 (2.6%) | 1 (3.7%) | 1.000 |
Dementia | 2 (5.1%) | 0 | 0.509 |
Congestive heart failure | 2 (5.1%) | 0 | 0.509 |
Previous surgeries | |||
TUI-BN | 9 (23.1%) | 3 (11.1%) | 0.332 |
Spinal surgery | 4 (10.3%) | 3 (11.1%) | 1.000 |
Pelvic surgery | 6 (15.4%) | 12 (44.4%) | 0.009 |
VUDS Parameter | Failure (n = 39) | Successful (n = 27) | p-Value |
---|---|---|---|
Follow-up period | 9.3 ± 6.7 | 7.7 ± 5.2 | 0.295 |
Age (years) | 54.4 ± 16.4 | 62.4 ± 13.1 | 0.038 |
FSF (mL) | 114.3 ± 52.7 | 138.2 ± 81.7 | 0.154 |
FS (mL) | 192.8 ± 84.3 | 212.4 ± 98.6 | 0.388 |
US (mL) | 230.1 ± 97.1 | 257.3 ± 117.8 | 0.310 |
Pdet (cm H2O) | 45.4 ± 27.2 | 55.2 ± 28.2 | 0.164 |
Qmax (mL/s) | 10.7 ± 7.3 | 7.1 ± 6.0 | 0.038 |
Volume (mL) | 177.8 ± 116.4 | 97.1 ± 69.0 | 0.002 |
PVR (mL) | 70.4 ± 99.7 | 223.2 ± 177.9 | <0.001 |
VE | 0.74 ± 0.23 | 0.35 ± 0.25 | <0.001 |
BOOI | 27.8 ± 32.0 | 39.3 ± 31.2 | 0.151 |
BCI | 89.6 ± 35.6 | 94.8 ± 37.4 | 0.569 |
VUDS DV subtype | |||
Mid-urethral | 30 (76.9%) | 17 (63.0%) | 0.353 |
Distal urethral | 7 (17.9%) | 9 (33.3%) | |
BND | 2 (5.1%) | 1 (3.7%) |
VUDS Parameter | Failure (n = 39) | p-Value | Successful (n = 27) | p-Value | Δp-Value | |
---|---|---|---|---|---|---|
FSF (mL) | BL F/U | 114.3 ± 52.7 128.9 ± 53.7 | 0.183 | 138.2 ± 81.7 138.7 ± 68.6 | 0.976 | 0.505 |
FS (mL) | BL F/U | 192.8 ± 84.3 202.4 ± 86.2 | 0.495 | 212.4 ± 98.6 228.0 ± 108.0 | 0.503 | 0.818 |
US (mL) | BL F/U | 230.1 ± 97.1 233.3 ± 104.0 | 0.813 | 257.3 ± 117.8 252.5 ± 109.3 | 0.842 | 0.771 |
Pdet (cm H2O) | BL F/U | 45.4 ± 27.2 42.9 ± 31.2 | 0.633 | 55.2 ± 28.2 46.3 ± 31.0 | 0.079 | 0.394 |
Qmax (mL/s) | BL F/U | 10.7 ± 7.3 10.9 ± 7.9 | 0.777 | 7.1 ± 6.0 14.4 ± 7.4 | <0.001 | <0.001 |
Volume (mL) | BL F/U | 177.8 ± 116.4 200.0 ± 130.7 | 0.206 | 97.1 ± 69.0 222.1 ± 106.4 | <0.001 | 0.001 |
PVR (mL) | BL F/U | 70.4 ± 99.7 98.1 ± 112.3 | 0.061 | 223.2 ± 117.9 104.9 ± 106.8 | <0.001 | <0.001 |
VE | BL F/U | 0.74 ± 0.23 0.68 ± 0.28 | 0.016 | 0.35 ± 0.25 0.70 ± 0.24 | <0.001 | <0.001 |
BOOI | BL F/U | 27.8 ± 32.0 27.7 ± 31.5 | 0.990 | 39.3 ± 31.2 24.9 ± 37.3 | 0.002 | 0.050 |
BCI | BL F/U | 89.6 ± 35.6 81.0 ± 46.3 | 0.265 | 94.8 ± 37.4 99.8 ± 35.6 | 0.571 | 0.248 |
Univariate | Multivariate | |||
---|---|---|---|---|
Variables | OR (95% CI) | p-Value | OR (95% CI) | p-Value |
Age (years) | 1.037 (1.001–1.075) | 0.043 | 0.990 (0.945–1.038) | 0.687 |
FSF (mL) | 1.006 (0.998–1.014) | 0.169 | ||
FS (mL) | 1.002 (0.997–1.008) | 0.384 | ||
US (mL) | 1.002 (0.998–1.007) | 0.306 | ||
Pdet (cm H2O) | 1.013 (0.995–1.032) | 0.165 | ||
Qmax (mL/s) | 0.913 (0.834–0.999) | 0.048 | 1.047 (0.920–1.191) | 0.486 |
VE | 0.003 (0.000–0.045) | <0.001 | 0.001 (0.000–0.034) | <0.001 |
BOOI | 1.012 (0.996–1.028) | 0.153 | ||
BCI | 1.004 (0.990–1.018) | 0.563 | ||
VUDS DV subtype | 0.365 | |||
Mid-urethral | Ref. | |||
Distal urethral | 2.269 (0.716–7.188) | |||
BND | 0.882 (0.074–10.464) | |||
Botox injection(s) | 0.453 | |||
Single injection | Ref. | |||
Repeat injections | 0.686 (0.256–1.838) | |||
Comorbidities | ||||
Hypertension | 2.154 (0.787–5.893) | 0.135 | ||
Diabetes mellitus | 1.356 (0.425–4.325) | 0.607 | ||
CAD | 0.700 (0.119–4.123) | 0.693 | ||
CKD | 1.480 (0.195–11.208) | 0.704 | ||
CVA | 1.462 (0.087–24.430) | 0.792 | ||
Dementia | 0.000 (0.000) | 0.999 | ||
CHF | 0.000 (0.000) | 0.999 | ||
Previous surgeries | ||||
TUI-BN | 0.417 (0.101–1.711) | 0.224 | ||
Spinal surgery | 1.094 (0.224–5.334) | 0.912 | ||
Pelvic surgery | 4.400 (1.387–13.959) | 0.012 | 6.643 (1.223–36.073) | 0.028 |
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Yang, C.-C.; Jiang, Y.-H.; Kuo, H.-C. Predictive Factors for the Successful Outcome of Urethral Sphincter Injections of Botulinum Toxin A for Non-Neurogenic Dysfunctional Voiding in Women. Toxins 2024, 16, 386. https://doi.org/10.3390/toxins16090386
Yang C-C, Jiang Y-H, Kuo H-C. Predictive Factors for the Successful Outcome of Urethral Sphincter Injections of Botulinum Toxin A for Non-Neurogenic Dysfunctional Voiding in Women. Toxins. 2024; 16(9):386. https://doi.org/10.3390/toxins16090386
Chicago/Turabian StyleYang, Chia-Cheng, Yuan-Hong Jiang, and Hann-Chorng Kuo. 2024. "Predictive Factors for the Successful Outcome of Urethral Sphincter Injections of Botulinum Toxin A for Non-Neurogenic Dysfunctional Voiding in Women" Toxins 16, no. 9: 386. https://doi.org/10.3390/toxins16090386
APA StyleYang, C.-C., Jiang, Y.-H., & Kuo, H.-C. (2024). Predictive Factors for the Successful Outcome of Urethral Sphincter Injections of Botulinum Toxin A for Non-Neurogenic Dysfunctional Voiding in Women. Toxins, 16(9), 386. https://doi.org/10.3390/toxins16090386