Long-Term Pulmonary Damage in Surviving Antitoxin-Treated Mice following a Lethal Ricin Intoxication
Abstract
:1. Introduction
2. Results
2.1. Long-Term Body Weight and Body Temperature Changes in Antitoxin-Treated Mice That Survived Ricin Intoxication
2.2. Pulmonary Damage Characterization in Surviving (Antitoxin-Treated) Mice
2.2.1. Histological and Immunohistological Evaluation
2.2.2. Lung Weight to Body Weight Ratio
2.2.3. Lung Compliance
3. Discussion
4. Materials and Methods
4.1. Ricin Preparation
4.2. Anti-Ricin Antitoxin
4.3. Animal Studies
4.4. Histology
4.5. Immunohistochemistry
4.6. Assessment of Lung Compliance
4.7. Statistical Analysis
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Gal, Y.; Sapoznikov, A.; Lazar, S.; Shoseyov, D.; Aftalion, M.; Gutman, H.; Evgy, Y.; Gez, R.; Nevo, R.; Falach, R. Long-Term Pulmonary Damage in Surviving Antitoxin-Treated Mice following a Lethal Ricin Intoxication. Toxins 2024, 16, 103. https://doi.org/10.3390/toxins16020103
Gal Y, Sapoznikov A, Lazar S, Shoseyov D, Aftalion M, Gutman H, Evgy Y, Gez R, Nevo R, Falach R. Long-Term Pulmonary Damage in Surviving Antitoxin-Treated Mice following a Lethal Ricin Intoxication. Toxins. 2024; 16(2):103. https://doi.org/10.3390/toxins16020103
Chicago/Turabian StyleGal, Yoav, Anita Sapoznikov, Shlomi Lazar, David Shoseyov, Moshe Aftalion, Hila Gutman, Yentl Evgy, Rellie Gez, Reinat Nevo, and Reut Falach. 2024. "Long-Term Pulmonary Damage in Surviving Antitoxin-Treated Mice following a Lethal Ricin Intoxication" Toxins 16, no. 2: 103. https://doi.org/10.3390/toxins16020103