Assessing the Use of BotulinumtoxinA for Hyperactive Urinary Tract Dysfunction a Decade After Approval: General Versus Local Anesthesia for BotulinumtoxinA Detrusor Injection

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

In this study, the authors examined the use of botulinum toxin injections into the bladder for patients with hyperactive bladders. The main focus was the preference in anesthesia used to perform these injections. The study's main finding is that despite higher fear and pain associated with local anesthesia (LA), it is preferred over general anesthesia (GA). This is an important finding. 

It was also interesting to note that there was a significant decrease in anxiety score in the first vs repeat injections which was also a significant finding. 

The statistical tests used were also described and are appropriate for this study. 

Author Response

Please see the attachment. Further, you find the red-tracked version under "manuscript", and the final clean version under "supplement".

Author Response File: Author Response.pdf

Reviewer 2 Report

Comments and Suggestions for Authors

 

Dear Authors,

Manuscript entitled „ Assessing the Use of BotulinumtoxinA for Hyperactive Urinary Tract Dysfunction a Decade after Approval: General versus Local Anesthesia for BotulinumtoxinA Detrusor Injection” is an interesting, well-written and well-planned experimental work. I fully support the publication of this manuscript; however I recommend some small corrections according to the comments:

 

Abstract

Line 15 – explain in full name an abbreviation VAS

Line 21 - explain in full name an abbreviation APAIS

Introduction

Line 39 - explain in full name an abbreviation FDA

Line 40 - explain in full name an abbreviation MS

Line 44 - explain in full name an abbreviation BoNT/A

Line 49, 50 - explain in full name abbreviations ATP, CGRP

Line 54 - explain in full name an abbreviation TRPV1

Line 67 - explain in full name an abbreviation GRACE

Results

Table 1 - explain in full name all abbreviations which appear for the first time in the description of Tables or figures: OnabotA; SD; W; M; OAB; nDO. Moreover, an abbreviation iOAB should be used instead of OAB

Line 151 - explain in full name abbreviations UDI-6, IIQ-7

Line 152 - explain in full name an abbreviation SSI score

Discussion

Line 200 - explain in full name an abbreviation VAS

Materials and Methods

Line 226 – live only an abbreviation OnabotA-DI, remove a full name

Line 237 - explain in full name an abbreviation PSA

Line 240 - live only an abbreviation APAIS, remove a full name

Line 262 - live only an abbreviation VAS, remove a full name

References

please prepare a list of publications in accordance with the rules required by the journal:

References should be described as follows, depending on the type of work:

Journal Articles:

1. Author 1, A.B.; Author 2, C.D. Title of the article. Abbreviated Journal Name Year, Volume, page range.

 

 

 

 

 

 

Author Response

Please see the attachment. Further, you find the red-tracked version under "manuscript", and the final clean version under "supplement".

Author Response File: Author Response.pdf

Reviewer 3 Report

Comments and Suggestions for Authors

I have carefully review manuscript entitled “Assessing the Use of Botulinumtoxin A for Hyperactive Urinary 2 Tract Dysfunction a Decade after Approval: General versus Local Anesthesia for Botulinumtoxin A Detrusor Injection’ and found interesting, although I have some major points for betterment of manuscript:

1. Author should add schematic representation for whole study for better visualization.

2. Author should correct the references?

3. figure 2 not clearly defined, please rearrange and define correctly.

4. Please add footnote in table1 and table 2.

5.Please mention ethical approval details?

 

 

Comments on the Quality of English Language

NA

Author Response

Please see the attachment. Further, you find the red-tracked version under "manuscript", and the final clean version under "supplement".

Author Response File: Author Response.pdf