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Microbiology Research
Volume 3
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10.4081/mr.2012.e3
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Article

Modulation of Mice Fecal Microbiota by Administration of Casein Glycomacropeptide

by
Qingsen Chen
*,
Jinyi Cao
,
Yuchen Jia
,
Xueji Liu
,
Yali Yan
and
Guangchang Pang
The Tianjin Key Laboratory of Food Biotechnology College of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, China
*
Author to whom correspondence should be addressed.
Microbiol. Res. 2012, 3(1), e3; https://doi.org/10.4081/mr.2012.e3
Submission received: 15 August 2011 / Revised: 12 November 2011 / Accepted: 12 November 2011 / Published: 21 December 2012

Abstract

Casein glycomacropeptide (GMP) is known to promote the in vitro growth of Bifidobacteria and Lactobacilli. In this paper, we used conventional culture techniques and fluorescent in situ hybridization (FISH) techniques to investigate the effect of casein GMP on mice fecal microbiota. The population structure of the intestinal microbiota, including Lactobacillus, Bifidobacteria, Enterococcus, coliforms and Enterobacteriaceae, was tested and compared. After consecutive administration of casein GMP for 15 days, numbers of Lactobacillus and Bifidobacteria increased significantly (P < 0.01), numbers of Enterobacteriaceae and Coliforms decreased significantly (P < 0.05) while no significant changes were observed for Enterococcus. The detection limits of FISH technique were significantly lower (P < 0.01) than the traditional culture method. These results suggested that consumption of casein GMP had a prebiotic effect on male BALB/c mice. Casein GMP helped establish a healthier intestinal microbiota. Additionally, FISH was proved to be a rapid and relatively low-cost detection method that can be used to further our understanding of human intestinal microbiota.
Keywords: casein glycomacropeptide (GMP); fecal microbiota; fluorescent in situ hybridization (FISH) techniques; traditional culture method casein glycomacropeptide (GMP); fecal microbiota; fluorescent in situ hybridization (FISH) techniques; traditional culture method

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MDPI and ACS Style

Chen, Q.; Cao, J.; Jia, Y.; Liu, X.; Yan, Y.; Pang, G. Modulation of Mice Fecal Microbiota by Administration of Casein Glycomacropeptide. Microbiol. Res. 2012, 3, e3. https://doi.org/10.4081/mr.2012.e3

AMA Style

Chen Q, Cao J, Jia Y, Liu X, Yan Y, Pang G. Modulation of Mice Fecal Microbiota by Administration of Casein Glycomacropeptide. Microbiology Research. 2012; 3(1):e3. https://doi.org/10.4081/mr.2012.e3

Chicago/Turabian Style

Chen, Qingsen, Jinyi Cao, Yuchen Jia, Xueji Liu, Yali Yan, and Guangchang Pang. 2012. "Modulation of Mice Fecal Microbiota by Administration of Casein Glycomacropeptide" Microbiology Research 3, no. 1: e3. https://doi.org/10.4081/mr.2012.e3

APA Style

Chen, Q., Cao, J., Jia, Y., Liu, X., Yan, Y., & Pang, G. (2012). Modulation of Mice Fecal Microbiota by Administration of Casein Glycomacropeptide. Microbiology Research, 3(1), e3. https://doi.org/10.4081/mr.2012.e3

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