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Microbiology Research
Volume 2
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10.4081/mr.2011.e16
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Article

Sequence Characterization of Matrix Protein (M1) in Influenza a Viruses (H1, H3 and H5)

by
Jun Zhang
1,
Xiao Ling Yu
1,
Lei Xu
1,
Fang Zhi Li
1 and
Yong Gang Li
2,*
1
Department of Respiratory Diseases, The Forth Hospital Affiliated to China Medical University, China
2
Department of Virology, Research Institute for Microbial Diseases, Osaka University, Japan
*
Author to whom correspondence should be addressed.
Microbiol. Res. 2011, 2(2), e16; https://doi.org/10.4081/mr.2011.e16
Submission received: 25 May 2011 / Revised: 25 May 2011 / Accepted: 2 September 2011 / Published: 7 October 2011

Abstract

This study brings the analysis of amino acid sequences of matrix protein (M1) from the influenza virus A (H1N1, H3N2 and H5N1) during 2007-2208. 741 sequences of M1 were compared, of them, H1N1 388; H3N2 251 and H5N1 102. Even though, the M1 is relatively conserved among the influenza A viruses, we found some variations in the M1 among the viruses, H1N1, H3N2 and H5N1. The nuclear localization signal at amino acid 101 to 105 is RKLKR for H1N1 and H3N2, but for H5N1 is KKLKR. All differences of amino acid in M1 of H1, H3 and H5 were listed. 80 sequences of M1 of H1N1 H3N2 and H5N1 were used for phylogenetic analysis. There is no reasontantment found in the M1 among these subtypes. Further study is needed to study the differences of the function of M1 among H1N1, H3N2 and H5N1. The M1 of H5N1 may contribute to the high pathogenesis to this virus.
Keywords: influenza virus A; H1N1; H3N2; H5N1; matrix protein (M1) influenza virus A; H1N1; H3N2; H5N1; matrix protein (M1)

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MDPI and ACS Style

Zhang, J.; Yu, X.L.; Xu, L.; Li, F.Z.; Li, Y.G. Sequence Characterization of Matrix Protein (M1) in Influenza a Viruses (H1, H3 and H5). Microbiol. Res. 2011, 2, e16. https://doi.org/10.4081/mr.2011.e16

AMA Style

Zhang J, Yu XL, Xu L, Li FZ, Li YG. Sequence Characterization of Matrix Protein (M1) in Influenza a Viruses (H1, H3 and H5). Microbiology Research. 2011; 2(2):e16. https://doi.org/10.4081/mr.2011.e16

Chicago/Turabian Style

Zhang, Jun, Xiao Ling Yu, Lei Xu, Fang Zhi Li, and Yong Gang Li. 2011. "Sequence Characterization of Matrix Protein (M1) in Influenza a Viruses (H1, H3 and H5)" Microbiology Research 2, no. 2: e16. https://doi.org/10.4081/mr.2011.e16

APA Style

Zhang, J., Yu, X. L., Xu, L., Li, F. Z., & Li, Y. G. (2011). Sequence Characterization of Matrix Protein (M1) in Influenza a Viruses (H1, H3 and H5). Microbiology Research, 2(2), e16. https://doi.org/10.4081/mr.2011.e16

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