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Infectious Disease Reports
Volume 4
Issue 2
10.4081/idr.2012.e30
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Infectious Disease Reports is published by MDPI from Volume 12 Issue 3 (2020). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Brief Report

Kinetics of HIV-1 in Cerebrospinal Fluid and Plasma in Cryptococcal Meningitis

by
Diego M. Cecchini
1,*,
Ana M. Cañizal
2,
Haroldo Rojas
1,
Alicia Arechavala
3,
Ricardo Negroni
3,
María B. Bouzas
2 and
Jorge A. Benetucci
1
1
Infectious Diseases Department, Hospital Francisco J Muñiz, Buenos Aires, Argentina
2
Virology Unit, Hospital Francisco J Muñiz, Buenos Aires, Argentina
3
Mycology Unit, Hospital Francisco J Muñiz, Buenos Aires, Argentina
*
Author to whom correspondence should be addressed.
Infect. Dis. Rep. 2012, 4(2), e30; https://doi.org/10.4081/idr.2012.e30
Submission received: 11 November 2011 / Revised: 23 March 2012 / Accepted: 4 April 2012 / Published: 24 April 2012

Abstract

In order to determine HIV-1 kinetics in cerebrospinal fluid (CSF) and plasma in patients with cryptococcal meningitis (CM), we undertook a prospective collection of paired CSF/plasma samples from antiretroviral therapy- free HIV-infected patients with CM. Samples were obtained at baseline (S1) and at the second (S2) and third (S3) weeks of antifungal therapy. HIV-1 CSF concentrations were significantly lower in both S2 and S3 with respect to S1. Plasma concentrations remained stable. HIV-1 concentrations were higher in plasma than CSF in all cases. Patients who survived the episode of CM (but not those who died) showed a decrease in CSF viral load, what suggests different viral kinetics of HIV-1 in the CSF according to the clinical course of this opportunistic disease.
Keywords: meningitis; HIV; Cryptococcus neoformans; cerebrospinal fluid meningitis; HIV; Cryptococcus neoformans; cerebrospinal fluid

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MDPI and ACS Style

Cecchini, D.M.; Cañizal, A.M.; Rojas, H.; Arechavala, A.; Negroni, R.; Bouzas, M.B.; Benetucci, J.A. Kinetics of HIV-1 in Cerebrospinal Fluid and Plasma in Cryptococcal Meningitis. Infect. Dis. Rep. 2012, 4, e30. https://doi.org/10.4081/idr.2012.e30

AMA Style

Cecchini DM, Cañizal AM, Rojas H, Arechavala A, Negroni R, Bouzas MB, Benetucci JA. Kinetics of HIV-1 in Cerebrospinal Fluid and Plasma in Cryptococcal Meningitis. Infectious Disease Reports. 2012; 4(2):e30. https://doi.org/10.4081/idr.2012.e30

Chicago/Turabian Style

Cecchini, Diego M., Ana M. Cañizal, Haroldo Rojas, Alicia Arechavala, Ricardo Negroni, María B. Bouzas, and Jorge A. Benetucci. 2012. "Kinetics of HIV-1 in Cerebrospinal Fluid and Plasma in Cryptococcal Meningitis" Infectious Disease Reports 4, no. 2: e30. https://doi.org/10.4081/idr.2012.e30

APA Style

Cecchini, D. M., Cañizal, A. M., Rojas, H., Arechavala, A., Negroni, R., Bouzas, M. B., & Benetucci, J. A. (2012). Kinetics of HIV-1 in Cerebrospinal Fluid and Plasma in Cryptococcal Meningitis. Infectious Disease Reports, 4(2), e30. https://doi.org/10.4081/idr.2012.e30

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