Risk Factors Associated with Poor Outcome in Patients with Infective Endocarditis: An Italian Single-Center Experience
Abstract
1. Introduction
2. Materials and Methods
3. Results
Study Population
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Age, Year | 65.6 ± 17.4 |
---|---|
Sex: | |
M | 46 (67.6%) |
F | 22 (32.4%) |
Drug addiction | 10 (14.7%) |
Duration of hospitalization, d | 23.9 ± 15 |
Heart Valve: | |
• Native valve; | 44 (64.7%) |
• Mechanical valve; | 24 (35.3%) |
• Early onset; | 3 (12.5%) |
• Late onset. | 21 (87.5%) |
Comorbidities: | |
• Diabetes mellitus; | 23 (33.8%) |
• Hypertension; | 42 (61.8%) |
• Heart failure; | 7 (10.3%) |
• Ischemic heart disease; | 11 (16.2%) |
• Chronic renal failure; | 11 (16.2%) |
• Immunosuppression. | 4 (5.9%) |
Hb, g/dL | 11.10 ± 2.04 |
WBC, cell/mm3 | 12,390 ± 6430 |
PLT, cell/mm3 | 205,560 ± 110,800 |
INR | 1.34 ± 0.49 |
ERS, mm/h | 40.6 ± 35.21 |
PCR, mg/dL | 12.2 ± 14.85 |
PCT, ng/mL | |
- Basal | 7.43 ± 20.27 |
- 48–72 h | 3.59 ± 13.10 |
48–72 h | |
eGFR, mL/min/1.73 m2 | 76.7 ± 38.2 |
Troponin, U/L | 0.74 ± 2.60 |
LDH, U/L | 630 ± 470 |
NT-Pro-BNP, pg/mL | 3653.3 ± 848 |
Ejection fraction, % | 59.4 ± 8.01 |
Clinical Manifestation | N (%) |
---|---|
Fever (with or without chills) | 50 (73.6) |
Cutaneous manifestations | 14 (20.6) |
Focal neurologic deficits | 7 (10.3) |
Asthenia and non-specific symptoms | 17 (25.1) |
New-onset heart murmur | 42 (61.8) |
Embolization | N (%) |
---|---|
Splenic | 7 (10.3) |
Pulmonary | 8 (11.7) |
Mixed (splenic ± renal, ± lower limbs, ± mesenteric) | 5 (7.3) |
Cerebral embolization | 7 (10.3) |
Total embolic events | 27 (39.6) |
Pearson R | p-Value | |||||
---|---|---|---|---|---|---|
Discharge | 30 Days | 6 Months | Discharge | 30 Days | 6 Months | |
Age | 0.346 | 0.386 | 0.386 | 0.004 | 0.001 | 0.001 |
eGFR | −0.343 | −0.437 | −0.425 | 0.004 | <0.001 | <0.001 |
Basal PCT | 0.266 | 0.337 | 0.339 | 0.029 | 0.005 | 0.005 |
48–72 h PCT | 0.222 | 0.308 | 0.305 | 0.049 | 0.011 | 0.011 |
New-onset heart murmur | 0.311 | 0.273 | 0.294 | 0.010 | 0.025 | 0.015 |
Non-continued antibiotic therapy | 0.232 | 0.239 | 0.283 | 0.050 | 0.05 | 0.019 |
Neurological manifestations | - | - | 0.284 | - | - | 0.019 |
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Ucciferri, C.; Auricchio, A.; Cutone, C.; Di Gasbarro, A.; Vecchiet, J.; Falasca, K. Risk Factors Associated with Poor Outcome in Patients with Infective Endocarditis: An Italian Single-Center Experience. Infect. Dis. Rep. 2022, 14, 213-219. https://doi.org/10.3390/idr14020026
Ucciferri C, Auricchio A, Cutone C, Di Gasbarro A, Vecchiet J, Falasca K. Risk Factors Associated with Poor Outcome in Patients with Infective Endocarditis: An Italian Single-Center Experience. Infectious Disease Reports. 2022; 14(2):213-219. https://doi.org/10.3390/idr14020026
Chicago/Turabian StyleUcciferri, Claudio, Antonio Auricchio, Carmine Cutone, Alessandro Di Gasbarro, Jacopo Vecchiet, and Katia Falasca. 2022. "Risk Factors Associated with Poor Outcome in Patients with Infective Endocarditis: An Italian Single-Center Experience" Infectious Disease Reports 14, no. 2: 213-219. https://doi.org/10.3390/idr14020026
APA StyleUcciferri, C., Auricchio, A., Cutone, C., Di Gasbarro, A., Vecchiet, J., & Falasca, K. (2022). Risk Factors Associated with Poor Outcome in Patients with Infective Endocarditis: An Italian Single-Center Experience. Infectious Disease Reports, 14(2), 213-219. https://doi.org/10.3390/idr14020026