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Gastroenterology Insights
Volume 10
Issue 1
10.4081/gi.2019.8256
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Gastroenterology Insights is published by MDPI from Volume 11 Issue 1 (2020). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Article

Clarithromycin versus Levofloxacin-Based Regimens for Helicobacter Pylori Eradication in the Kurdistan Region of Iraq: A Randomized Clinical Trial

by
Shinah A. Mohammed
1,
Omer Q. B. Al-lela
1,*,
Nawfal R. Hussein
1,
Ramadhan S. Hajany
1 and
Laween S. Alduhoky
1
1
College of Pharmacy, University of Duhok, Duhok, Kurdistan Region
2
College of Pharmacy, University of Duhok, Duhok, Kurdistan Region; Department of Pharmacy, Al-Noor University College
3
College of Medicine, University of Zakho, Kurdistan Region
4
College of Medicine, University of Duhok, Duhok, Kurdistan Region
5
Azadi Teaching Hospital, Duhok, Kurdistan Region
*
Author to whom correspondence should be addressed.
Gastroenterol. Insights 2019, 10(1), 8256; https://doi.org/10.4081/gi.2019.8256
Submission received: 27 July 2019 / Accepted: 16 August 2019 / Published: 17 September 2019

Abstract

Helicobacter pylori infection is a predisposing factor for gastric cancer. This prospective, randomized clinical trial aimed to compare H. pylori eradication rates associated with a clarithromycin-based regimen and levofloxacin-based regimen. H. pylori infection was confirmed by a rapid urease test during endoscopy and its eradication by a urea breath test. In this study, 192 patients were recruited; 93 patients received a clarithromycin- based regimen and 99 a levofloxacin- based regimen. Sixty-four patients completed the clarithromycinbased regimen and 60 the levofloxacinbased regimen. The eradication success rate of the clarithromycin-based regimen was 52/64 (81.25%), while that of the levofloxacin- based regimen was 49/60 (81.6%) (P=0.9524; odds ratio [OR]=1.0280; confidence interval [CI]=0.4153-2.5447). Investigation of the risk factors associated with treatment failure showed that the overall efficacy of the regimens was influenced by body mass index (BMI), with a high failure rate observed in patients with a high BMI (P=0.0174; OR=1.1116; CI=1.0187- 1.2129). Age, sex, endoscopic diagnosis and smoking did not influence treatment outcomes. Further studies are needed to monitor H. pylori antibiotic resistance rates.
Keywords: Helicobacter pylori; Eradication; Levofloxacin; Clarithromycin; Duhok; Iraq Helicobacter pylori; Eradication; Levofloxacin; Clarithromycin; Duhok; Iraq

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MDPI and ACS Style

Mohammed, S.A.; Al-lela, O.Q.B.; Hussein, N.R.; Hajany, R.S.; Alduhoky, L.S. Clarithromycin versus Levofloxacin-Based Regimens for Helicobacter Pylori Eradication in the Kurdistan Region of Iraq: A Randomized Clinical Trial. Gastroenterol. Insights 2019, 10, 8256. https://doi.org/10.4081/gi.2019.8256

AMA Style

Mohammed SA, Al-lela OQB, Hussein NR, Hajany RS, Alduhoky LS. Clarithromycin versus Levofloxacin-Based Regimens for Helicobacter Pylori Eradication in the Kurdistan Region of Iraq: A Randomized Clinical Trial. Gastroenterology Insights. 2019; 10(1):8256. https://doi.org/10.4081/gi.2019.8256

Chicago/Turabian Style

Mohammed, Shinah A., Omer Q. B. Al-lela, Nawfal R. Hussein, Ramadhan S. Hajany, and Laween S. Alduhoky. 2019. "Clarithromycin versus Levofloxacin-Based Regimens for Helicobacter Pylori Eradication in the Kurdistan Region of Iraq: A Randomized Clinical Trial" Gastroenterology Insights 10, no. 1: 8256. https://doi.org/10.4081/gi.2019.8256

APA Style

Mohammed, S. A., Al-lela, O. Q. B., Hussein, N. R., Hajany, R. S., & Alduhoky, L. S. (2019). Clarithromycin versus Levofloxacin-Based Regimens for Helicobacter Pylori Eradication in the Kurdistan Region of Iraq: A Randomized Clinical Trial. Gastroenterology Insights, 10(1), 8256. https://doi.org/10.4081/gi.2019.8256

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