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Volume 11
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10.1080/20016689.2023.2166374
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Journal of Market Access & Health Policy (JMAHP) is published by MDPI from Volume 12 Issue 1 (2024). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Taylor & Francis.
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Article

Health-Related Quality of Life in Health States Corresponding to Different Stages of Perianal Fistula Associated with Crohn’s Disease: A Quantitative Evaluation of Patients and Non-Patients in Japan

by
Masafumi Kato
1,*,
Mariko Yoneyama-Hirozane
1,
Katsuhiko Iwasaki
2,
Mao Matsubayashi
3 and
Ataru Igarashi
4,5
1
Japan Pharma Business Unit, Takeda Pharmaceutical Company Limited, Tokyo, Japan
2
Department of Data Science, Medilead, Inc, Tokyo, Japan
3
Department of Gastroenterology, Graduate School of Medicine, Yokohama City University, Yokohama, Japan
4
Unit of Public Health and Preventive Medicine, School of Medicine, Yokohama City University, Yokohama, Japan
5
Department of Health Economics and Outcomes Research, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
*
Author to whom correspondence should be addressed.
J. Mark. Access Health Policy 2023, 11(1), 2166374; https://doi.org/10.1080/20016689.2023.2166374
Submission received: 19 June 2022 / Revised: 26 December 2022 / Accepted: 3 January 2023 / Published: 15 January 2023

Abstract

ABSTRACT Background: Perianal fistula (PF), a complication of Crohn’s disease (CD), affects health-related quality of life (QOL). Objective: To elucidate QOL of health states corresponding to different stages of PF associated with CD in Japan. Method: This cross-sectional, observational, web-based questionnaire survey assessed eight different health states in patients with CD and PF and individuals without CD (non-patients) from the Medilead Healthcare Panel (MHP) and determined the utility values (QOL scores) in each health state by the time trade-off method. In patients, we determined also the utility value of the current health state associated with CD and the PF. The analysis excluded respondents with logical inconsistencies. Results: The analysis included 82 patients and 576 non-patients with the same sex and age distribution as the Japanese population. In both groups, mean utility values were higher in remission (patients, 0.78; non-patients, 0.51) than in non-remission states, with lowest values for poor prognosis after proctectomy (patients, 0.13; non-patients, −0.10) and highest values for the state with mild symptoms (patients, 0.60; non-patients, 0.30). In patients, the mean utility value of the current health state was 0.71. Conclusion: QOL decreases with increasing severity of PF and is lower for good prognosis after proctostomy than for remission.
Keywords: Japanese; Crohn’s disease; perianal fistula; quality of life; utility value; time trade-off Japanese; Crohn’s disease; perianal fistula; quality of life; utility value; time trade-off

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MDPI and ACS Style

Kato, M.; Yoneyama-Hirozane, M.; Iwasaki, K.; Matsubayashi, M.; Igarashi, A. Health-Related Quality of Life in Health States Corresponding to Different Stages of Perianal Fistula Associated with Crohn’s Disease: A Quantitative Evaluation of Patients and Non-Patients in Japan. J. Mark. Access Health Policy 2023, 11, 2166374. https://doi.org/10.1080/20016689.2023.2166374

AMA Style

Kato M, Yoneyama-Hirozane M, Iwasaki K, Matsubayashi M, Igarashi A. Health-Related Quality of Life in Health States Corresponding to Different Stages of Perianal Fistula Associated with Crohn’s Disease: A Quantitative Evaluation of Patients and Non-Patients in Japan. Journal of Market Access & Health Policy. 2023; 11(1):2166374. https://doi.org/10.1080/20016689.2023.2166374

Chicago/Turabian Style

Kato, Masafumi, Mariko Yoneyama-Hirozane, Katsuhiko Iwasaki, Mao Matsubayashi, and Ataru Igarashi. 2023. "Health-Related Quality of Life in Health States Corresponding to Different Stages of Perianal Fistula Associated with Crohn’s Disease: A Quantitative Evaluation of Patients and Non-Patients in Japan" Journal of Market Access & Health Policy 11, no. 1: 2166374. https://doi.org/10.1080/20016689.2023.2166374

APA Style

Kato, M., Yoneyama-Hirozane, M., Iwasaki, K., Matsubayashi, M., & Igarashi, A. (2023). Health-Related Quality of Life in Health States Corresponding to Different Stages of Perianal Fistula Associated with Crohn’s Disease: A Quantitative Evaluation of Patients and Non-Patients in Japan. Journal of Market Access & Health Policy, 11(1), 2166374. https://doi.org/10.1080/20016689.2023.2166374

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