Pharmaceutics 2017, 9(2), 12; https://doi.org/10.3390/pharmaceutics9020012
Liposomal Formulations in Clinical Use: An Updated Review
Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hyderabad 500037, India
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Received: 16 January 2017 / Revised: 20 March 2017 / Accepted: 23 March 2017 / Published: 27 March 2017
(This article belongs to the Special Issue Nanotechnology in Medical Therapeutic Formulations)
Abstract
Liposomes are the first nano drug delivery systems that have been successfully translated into real-time clinical applications. These closed bilayer phospholipid vesicles have witnessed many technical advances in recent years since their first development in 1965. Delivery of therapeutics by liposomes alters their biodistribution profile, which further enhances the therapeutic index of various drugs. Extensive research is being carried out using these nano drug delivery systems in diverse areas including the delivery of anti-cancer, anti-fungal, anti-inflammatory drugs and therapeutic genes. The significant contribution of liposomes as drug delivery systems in the healthcare sector is known by many clinical products, e.g., Doxil®, Ambisome®, DepoDur™, etc. This review provides a detailed update on liposomal technologies e.g., DepoFoam™ Technology, Stealth technology, etc., the formulation aspects of clinically used products and ongoing clinical trials on liposomes. View Full-TextKeywords:
liposomes; therapeutics; drug delivery; liposome technology; nanotechnology; clinical trials; marketed products
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Bulbake, U.; Doppalapudi, S.; Kommineni, N.; Khan, W. Liposomal Formulations in Clinical Use: An Updated Review. Pharmaceutics 2017, 9, 12.
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