Next Article in Journal
Lobular Distribution and Variability in Hepatic ATP Binding Cassette Protein B1 (ABCB1, P-gp): Ontogenetic Differences and Potential for Toxicity
Previous Article in Journal
Acknowledgement to Reviewers of Pharmaceutics in 2016
Article Menu
Issue 1 (March) cover image

Export Article

Open AccessArticle
Pharmaceutics 2017, 9(1), 7;

Investigation of Drug–Polymer Compatibility Using Chemometric-Assisted UV-Spectrophotometry

Pharmaceutics and industrial pharmacy, Military Medical Academy, Cairo 00202, Egypt
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia
Medical services Department, Cairo 00202, Egypt
Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt
Authors to whom correspondence should be addressed.
Academic Editor: Afzal R. Mohammed
Received: 2 November 2016 / Revised: 28 December 2016 / Accepted: 3 January 2017 / Published: 16 January 2017
Full-Text   |   PDF [7187 KB, uploaded 16 January 2017]   |  


A simple chemometric-assisted UV-spectrophotometric method was used to study the compatibility of clindamycin hydrochloride (HC1) with two commonly used natural controlled-release polymers, alginate (Ag) and chitosan (Ch). Standard mixtures containing 1:1, 1:2, and 1:0.5 w/w drug–polymer ratios were prepared and UV scanned. A calibration model was developed with partial least square (PLS) regression analysis for each polymer separately. Then, test mixtures containing 1:1 w/w drug–polymer ratios with different sets of drug concentrations were prepared. These were UV scanned initially and after three and seven days of storage at 25 °C. Using the calibration model, the drug recovery percent was estimated and a decrease in concentration of 10% or more from initial concentration was considered to indicate instability. PLS models with PC3 (for Ag) and PC2 (for Ch) showed a good correlation between actual and found values with root mean square error of cross validation (RMSECV) of 0.00284 and 0.01228, and calibration coefficient (R2) values of 0.996 and 0.942, respectively. The average drug recovery percent after three and seven days was 98.1 ± 2.9 and 95.4 ± 4.0 (for Ag), and 97.3 ± 2.1 and 91.4 ± 3.8 (for Ch), which suggests more drug compatibility with an Ag than a Ch polymer. Conventional techniques including DSC, XRD, FTIR, and in vitro minimum inhibitory concentration (MIC) for (1:1) drug–polymer mixtures were also performed to confirm clindamycin compatibility with Ag and Ch polymers. View Full-Text
Keywords: clindamycin HCl; sodium alginate; chitosan; partial least squares regression (PLS); drug–polymer compatibility clindamycin HCl; sodium alginate; chitosan; partial least squares regression (PLS); drug–polymer compatibility

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Mohamed, A.I.; Abd-Motagaly, A.M.E.; Ahmed, O.A.A.; Amin, S.; Mohamed Ali, A.I. Investigation of Drug–Polymer Compatibility Using Chemometric-Assisted UV-Spectrophotometry. Pharmaceutics 2017, 9, 7.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Pharmaceutics EISSN 1999-4923 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top