Next Article in Journal
Practical Dynamic Contrast Enhanced MRI in Small Animal Models of Cancer: Data Acquisition, Data Analysis, and Interpretation
Previous Article in Journal
Diclofenac Salts, VIII. Effect of the Counterions on the Permeation through Porcine Membrane from Aqueous Saturated Solutions
Article Menu

Export Article

Open AccessArticle
Pharmaceutics 2012, 4(3), 430-441;

Influence of the Efavirenz Micronization on Tableting and Dissolution

Laboratory of Antibiotics, Biochemistry, Institute of Biology, Universidade Federal Fluminense, Campus of Valonguinho, Niterói, RJ, CEP: 24.210-130, Brazil
Institute of Drug Technology, Fundação Oswaldo Cruz, Av. Comandante Guaranys, 447, Curicica, Rio de Janeiro, RJ, CEP: 22.775-903, Brazil
Author to whom correspondence should be addressed.
Received: 8 August 2012 / Revised: 2 September 2012 / Accepted: 2 September 2012 / Published: 12 September 2012
Full-Text   |   PDF [590 KB, uploaded 12 September 2012]   |  


The purpose of this study was to propose an analytical procedure that provides the effects of particle size and surface area on dissolution of efavirenz. Five different batches obtained by different micronization processes and with different particle size distribution and surface area were studied. The preformulation studies and dissolution curves were used to confirm the particle size distribution effect on drug solubility. No polymorphic variety or amorphization was observed in the tested batches and the particle size distribution was determined as directly responsible for the improvement of drug dissolution. The influence of the preparation process on the tablets derived from efavirenz was observed in the final dissolution result in which agglomeration, usually seen in non-lipophilic micronized material, was avoided through the use of an appropriate wet granulation method. For these reasons, micronization may represent one viable alternative for the formulation of brick dust drugs. View Full-Text
Keywords: AIDS; size distribution; surface area; bioavailability; brick dust drug AIDS; size distribution; surface area; bioavailability; brick dust drug

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Pinto, E.C.; Carmo, F.A.; Honório, T.S.; Barros, R.C.S.A.; Castro, H.C.R.; Rodrigues, C.R.; Esteves, V.S.D.; Rocha, H.V.A.; Sousa, V.P.; Cabral, L.M. Influence of the Efavirenz Micronization on Tableting and Dissolution. Pharmaceutics 2012, 4, 430-441.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Pharmaceutics EISSN 1999-4923 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top