Next Article in Journal
Transporter-Mediated Drug–Drug Interactions with Oral Antidiabetic Drugs
Previous Article in Journal
Structural Versatility of Bicellar Systems and Their Possibilities as Colloidal Carriers
Article Menu

Export Article

Open AccessArticle
Pharmaceutics 2011, 3(4), 665-679;

Mucoadhesive Gels Designed for the Controlled Release of Chlorhexidine in the Oral Cavity

Department SMETEC, University of Bologna, Bologna, 40127, Italy
Monteresearch, Bollate, Milano, 20021, Italy
Author to whom correspondence should be addressed.
Received: 21 July 2011 / Revised: 9 September 2011 / Accepted: 26 September 2011 / Published: 27 September 2011
(This article belongs to the Special Issue The Progress on Pharmaceutics in Drug Delayed Release System)
Full-Text   |   PDF [247 KB, uploaded 27 September 2011]


This study describes the in vitro/ex vivo buccal release of chlorhexidine (CHX) from nine mucoadhesive aqueous gels, as well as their physicochemical and mucoadhesive properties: CHX was present at a constant 1% w/v concentration in the chemical form of digluconate salt. The mucoadhesive/gel forming materials were carboxymethyl- (CMC), hydroxypropylmethyl- (HPMC) and hydroxypropyl- (HPC) cellulose, alone (3% w/w) or in binary mixtures (5% w/w); gels were tested for their mucoadhesion using the mucin method at 1, 2 and 3% w/w concentrations. CHX release from different formulations was assessed using a USP method and newly developed apparatus, combining release/permeation process in which porcine mucosa was placed in a Franz cell. The combination of HPMC or HPC with CMC showed slower drug release when compared to each of the individual polymers. All the systems proved suitable for CHX buccal delivery, being able to guarantee both prolonged release and reduced transmucosal permeation. Gels were compared for the release of previously studied tablets that contained Carbopol and HPMC, alone or in mixture. An accurate selection and combination of the materials allow the design of different pharmaceutical forms suitable for different purposes, by simply modifying the formulation compositions. View Full-Text
Keywords: chlorhexidine; mucoadhesive gels; release/permeation chlorhexidine; mucoadhesive gels; release/permeation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Fini, A.; Bergamante, V.; Ceschel, G.C. Mucoadhesive Gels Designed for the Controlled Release of Chlorhexidine in the Oral Cavity. Pharmaceutics 2011, 3, 665-679.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Pharmaceutics EISSN 1999-4923 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top