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Pharmaceutics 2011, 3(3), 601-614;

Co-Crystal Screening of Diclofenac

Department of Chemistry, Kansas State University, Manhattan, KS 66506, USA
Author to whom correspondence should be addressed.
Received: 28 June 2011 / Revised: 17 August 2011 / Accepted: 23 August 2011 / Published: 31 August 2011
(This article belongs to the Special Issue Pharmaceutical Salts and Co-Crystals)
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In the pharmaceutical industry, co-crystals are becoming increasingly valuable as crystalline solids that can offer altered/improved physical properties of an active pharmaceutical ingredient (API) without changing its chemical identity or biological activity. In order to identify new solid forms of diclofenac—an analgesic with extremely poor aqueous solubility for which few co-crystal structures have been determined—a range of pyrazoles, pyridines, and pyrimidines were screened for co-crystal formation using solvent assisted grinding and infrared spectroscopy with an overall success rate of 50%. The crystal structures of three new diclofenac co-crystals are reported herein: (diclofenac)∙(2-aminopyrimidine), (diclofenac)∙(2-amino-4,6-dimethylpyrimidine), and (diclofenac)∙(2-amino-4-chloro-6-methylpyrimidine). View Full-Text
Keywords: diclofenac; co-crystals; hydrogen bonding; crystallography; IR spectroscopy diclofenac; co-crystals; hydrogen bonding; crystallography; IR spectroscopy

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Aakeröy, C.B.; Grommet, A.B.; Desper, J. Co-Crystal Screening of Diclofenac. Pharmaceutics 2011, 3, 601-614.

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