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Pharmaceutics
Volume 17
Issue 7
10.3390/pharmaceutics17070893
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Review

Inhalable Nanotechnology-Based Drug Delivery Systems for the Treatment of Inflammatory Lung Diseases

by
Doaa Elsayed Mahmoud
1,
Seyedeh Hanieh Hosseini
2,
Hassaan Anwer Rathore
1,
Alaaldin M. Alkilany
1,
Andreas Heise
3 and
Abdelbary Elhissi
1,*
1
Department of Pharmaceutical Sciences, College of Pharmacy, QU Health, Qatar University, Doha 2713, Qatar
2
Department of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha 2713, Qatar
3
Department of Chemistry, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, D02 YN77 Dublin, Ireland
*
Author to whom correspondence should be addressed.
Pharmaceutics 2025, 17(7), 893; https://doi.org/10.3390/pharmaceutics17070893
Submission received: 3 June 2025 / Revised: 3 July 2025 / Accepted: 4 July 2025 / Published: 9 July 2025
(This article belongs to the Special Issue Recent Advances in Pulmonary Inhalation of Nanoformulations)
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Abstract

This review explores recent advancements in inhaled nanoparticle formulations and inhalation devices, with a focus on various types of nanoparticles used for inhalation to treat inflammatory lung diseases and the types of devices used in their delivery. Medical nebulizers have been found to be the most appropriate type of inhalation devices for the pulmonary delivery of nanoparticles, since formulations can be prepared using straightforward techniques, with no need for liquefied propellants as in the case of pressurized metered dose inhalers (pMDIs), or complicated preparation procedures as in the case of dry powder inhalers (DPIs). We demonstrated examples of how formulations should be designed considering the operation mechanism of nebulizers, and how an interplay of factors can affect the aerosol characteristics of nanoparticle formulations. Overall, nanoparticle-based formulations offer promising potential for the treatment of inflammatory lung diseases due to their unique physicochemical properties and ability to provide localized drug delivery in the lung following inhalation.
Keywords: nanoparticles; inhalation devices; drug delivery; inflammatory lung disorders nanoparticles; inhalation devices; drug delivery; inflammatory lung disorders

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MDPI and ACS Style

Mahmoud, D.E.; Hosseini, S.H.; Rathore, H.A.; Alkilany, A.M.; Heise, A.; Elhissi, A. Inhalable Nanotechnology-Based Drug Delivery Systems for the Treatment of Inflammatory Lung Diseases. Pharmaceutics 2025, 17, 893. https://doi.org/10.3390/pharmaceutics17070893

AMA Style

Mahmoud DE, Hosseini SH, Rathore HA, Alkilany AM, Heise A, Elhissi A. Inhalable Nanotechnology-Based Drug Delivery Systems for the Treatment of Inflammatory Lung Diseases. Pharmaceutics. 2025; 17(7):893. https://doi.org/10.3390/pharmaceutics17070893

Chicago/Turabian Style

Mahmoud, Doaa Elsayed, Seyedeh Hanieh Hosseini, Hassaan Anwer Rathore, Alaaldin M. Alkilany, Andreas Heise, and Abdelbary Elhissi. 2025. "Inhalable Nanotechnology-Based Drug Delivery Systems for the Treatment of Inflammatory Lung Diseases" Pharmaceutics 17, no. 7: 893. https://doi.org/10.3390/pharmaceutics17070893

APA Style

Mahmoud, D. E., Hosseini, S. H., Rathore, H. A., Alkilany, A. M., Heise, A., & Elhissi, A. (2025). Inhalable Nanotechnology-Based Drug Delivery Systems for the Treatment of Inflammatory Lung Diseases. Pharmaceutics, 17(7), 893. https://doi.org/10.3390/pharmaceutics17070893

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