Enhancement of Storage Stability and Masking Effect of Curcumin by Turmeric Extract-Loaded Nanoemulsion and Water-Soluble Chitosan Coating
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Preparation of Turmeric Extract-Loaded Nanoemulsions (TE-NEs)
2.3. Preparation of Water-Soluble Chitosan-Coated TE-NEs (WCS-TE-NEs)
2.4. Droplet Size, Polydispersity Index, and Zeta Potential
2.5. Encapsulation Efficiency
2.6. Temperature Stability of the WCS-TE-NEs
2.7. Ionic Strength Stability of the WCS-TE-NEs
2.8. pH Stability of the WCS-TE-NEs
2.9. FT-IR Spectroscopy
2.10. HPLC
2.11. Gas Chromatography
2.12. Transmission Electron Microscopy
2.13. Confocal Laser Scanning Microscopy
2.14. Statistical Analysis
3. Results
3.1. Characterization of TE-NEs and WCS-TE-NEs
3.2. Effect of the Ratio of TE-NEs to WCS Solution on the Particles Size, PDI, and Zeta Potential
3.3. Effect of the Ratio of TE-NEs to WCS Solution on the Encapsulation Efficiency
3.4. Effect of the Storage Temperature on the Particle Size and Zeta Potential
3.5. Effect of the NaCl Concentration and pH on the Content of Remained Curcumin
3.6. Physical Interaction of TE-NEs with Water-Soluble Chitosan
3.7. Effect of Encapsulation on Flavor Components
3.8. Morphology by Transmission Electron Microscopy
3.9. Confocal Analysis of TE-NEs and WCS-TE-NEs
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Compositions | ||||
---|---|---|---|---|
MCT Oil (g) | Surfactants | Distilled Water (g) | Turmeric Extract Powder (g) | |
Lecithin (g) | Tween 80 (g) | |||
7.5 | 4.1 | 3.4 | 85 | 1.5 |
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Lee, B.N.; Hong, S.J.; Yu, M.H.; Shin, G.H.; Kim, J.T. Enhancement of Storage Stability and Masking Effect of Curcumin by Turmeric Extract-Loaded Nanoemulsion and Water-Soluble Chitosan Coating. Pharmaceutics 2022, 14, 1547. https://doi.org/10.3390/pharmaceutics14081547
Lee BN, Hong SJ, Yu MH, Shin GH, Kim JT. Enhancement of Storage Stability and Masking Effect of Curcumin by Turmeric Extract-Loaded Nanoemulsion and Water-Soluble Chitosan Coating. Pharmaceutics. 2022; 14(8):1547. https://doi.org/10.3390/pharmaceutics14081547
Chicago/Turabian StyleLee, Bom Nae, Su Jung Hong, Mi Hee Yu, Gye Hwa Shin, and Jun Tae Kim. 2022. "Enhancement of Storage Stability and Masking Effect of Curcumin by Turmeric Extract-Loaded Nanoemulsion and Water-Soluble Chitosan Coating" Pharmaceutics 14, no. 8: 1547. https://doi.org/10.3390/pharmaceutics14081547