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Article

Arctiin Inhibits Cervical Cancer Cell Migration and Invasion through Suppression of S100A4 Expression via PI3K/Akt Pathway

1
Department of Obstetrics and Gynecology, Chiayi Chang Gung Memorial Hospital, Chiayi 613, Taiwan
2
Department of Nursing, Chang Gung University of Science and Technology, Chiayi Campus, Chiayi 613, Taiwan
3
Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
4
Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan
5
Institute of Oral Sciences, Chung Shan Medical University, Taichung 402, Taiwan
6
Department of Dentistry, Chung Shan Medical University Hospital, Taichung 402, Taiwan
7
Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung 402, Taiwan
8
School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
9
Department of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua 500, Taiwan
10
Women’s Health Research Laboratory, Changhua Christian Hospital, Changhua 500, Taiwan
*
Authors to whom correspondence should be addressed.
Academic Editors: Juan F. Santibanez, César A. Echeverría and Victor Hugo Villar
Pharmaceutics 2022, 14(2), 365; https://doi.org/10.3390/pharmaceutics14020365
Received: 5 January 2022 / Revised: 1 February 2022 / Accepted: 2 February 2022 / Published: 5 February 2022
(This article belongs to the Special Issue Current and Future Cancer Chemoprevention Strategies)
Arctiin, a lignan glycoside, is isolated from Arctium lappa L. The anticancer effects of arctiin have been demonstrated in several studies. However, no research has been conducted on the anti-migration effect of arctiin in cervical cancer cells. The present study examined the effects of arctiin on cervical cancer cells and investigated the possible molecular mechanism. We demonstrated that arctiin exhibited low cytotoxicity and significantly inhibited cell migration and invasion in human cervical cancer cells. The S100A4 protein expression and mRNA levels were significantly reduced in HeLa and SiHa cells with arctiin treatment. Furthermore, silencing S100A4 by using small interfering RNA reduced cell migration, while overexpression of S100A4 mitigated the migration inhibition imposed by arctiin in cervical cancer cells. Western blotting revealed that arctiin significantly reduced phosphoinositide 3-kinase (PI3K) and phosphorylation of Akt in cervical cancer cells. Moreover, selective Akt induction by an Akt activator, SC-79, reverted cervical cancer cell migration and S100A4 protein expression, which were reduced in response to arctiin. Taken together, these results suggest that arctiin inhibits cervical cancer cell migration and invasion through suppression of S100A4 and the PI3K/Akt pathway. View Full-Text
Keywords: arctiin; S100A4; migration; cervical cancer arctiin; S100A4; migration; cervical cancer
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MDPI and ACS Style

Lee, C.-Y.; Hsin, M.-C.; Chen, P.-N.; Lin, C.-W.; Wang, P.-H.; Yang, S.-F.; Hsiao, Y.-H. Arctiin Inhibits Cervical Cancer Cell Migration and Invasion through Suppression of S100A4 Expression via PI3K/Akt Pathway. Pharmaceutics 2022, 14, 365. https://doi.org/10.3390/pharmaceutics14020365

AMA Style

Lee C-Y, Hsin M-C, Chen P-N, Lin C-W, Wang P-H, Yang S-F, Hsiao Y-H. Arctiin Inhibits Cervical Cancer Cell Migration and Invasion through Suppression of S100A4 Expression via PI3K/Akt Pathway. Pharmaceutics. 2022; 14(2):365. https://doi.org/10.3390/pharmaceutics14020365

Chicago/Turabian Style

Lee, Chung-Yuan, Min-Chieh Hsin, Pei-Ni Chen, Chiao-Wen Lin, Po-Hui Wang, Shun-Fa Yang, and Yi-Hsuan Hsiao. 2022. "Arctiin Inhibits Cervical Cancer Cell Migration and Invasion through Suppression of S100A4 Expression via PI3K/Akt Pathway" Pharmaceutics 14, no. 2: 365. https://doi.org/10.3390/pharmaceutics14020365

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