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Article

Smart Shockwave Responsive Titania-Based Nanoparticles for Cancer Treatment

1
Department of Applied Science and Technology, Politecnico di Torino, C.so Duca Degli Abruzzi 24, 10129 Turin, Italy
2
Centro de Química Estrutural, Universidade de Lisboa, Av. Rovisco Pais, IST, 1000 Lisboa, Portugal
3
Centro de Ciências e Tecnologias Nucleares, Instituto Superior Técnico, Universidade de Lisboa, 2685-066 Bobadela, Portugal
4
Departamento de Engenharia Química, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1000 Lisboa, Portugal
*
Author to whom correspondence should be addressed.
These authors contributed equally.
Academic Editors: Marieta Costache and Bianca Gǎlǎţeanu
Pharmaceutics 2021, 13(9), 1423; https://doi.org/10.3390/pharmaceutics13091423
Received: 4 August 2021 / Revised: 1 September 2021 / Accepted: 3 September 2021 / Published: 8 September 2021
(This article belongs to the Special Issue Nanocarriers for Drug Delivery and/or Gene Therapy in Cancer)
Nanomedicine is an emerging treatment approach for many cancers, characterized by having high sensitivity and selectivity for tumor cells and minimal toxic effects induced by the conventional chemotherapeutics. In these context, smart nanoparticles (NPs) are getting increasingly relevant in the development of new therapies. NPs with specific chemical composition and/or structure and being stimuli-responsive to magnetic, light or ultrasound waves are new promising tools. In the present work, amorphous-titania propyl-amine functionalized (a-TiO2-NH2) NPs, coated with bovine serum albumin (BSA), are stimulated with high energy shock waves to induce cytotoxic effects in cancer cells. First, a new method to coat a-TiO2-NH2 NPs with BSA (a-TiO2-NH2/BSA) was proposed, allowing for a high dispersion and colloidal stability in a cell culture media. The a-TiO2-NH2/BSA NPs showed no cancer cell cytotoxicity. In a second step, the use of shock waves to stimulate a-TiO2-NH2/BSA NPs, was evaluated and optimized. A systematic study was performed in in vitro cell culture aiming to impair the cancer cell viability: NP concentrations, time steps and single versus multiple shock waves treatments were studied. The obtained results highlighted the relevance of NPs design and administration time point with respect to the shock wave treatment and allow to hypothesize mechanical damages to cells. View Full-Text
Keywords: amorphous titania nanoparticles; bovine serum albumin coating; shock waves; nanoparticles-assisted ultrasound amorphous titania nanoparticles; bovine serum albumin coating; shock waves; nanoparticles-assisted ultrasound
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MDPI and ACS Style

Vighetto, V.; Racca, L.; Canta, M.; Matos, J.C.; Dumontel, B.; Gonçalves, M.C.; Cauda, V. Smart Shockwave Responsive Titania-Based Nanoparticles for Cancer Treatment. Pharmaceutics 2021, 13, 1423. https://doi.org/10.3390/pharmaceutics13091423

AMA Style

Vighetto V, Racca L, Canta M, Matos JC, Dumontel B, Gonçalves MC, Cauda V. Smart Shockwave Responsive Titania-Based Nanoparticles for Cancer Treatment. Pharmaceutics. 2021; 13(9):1423. https://doi.org/10.3390/pharmaceutics13091423

Chicago/Turabian Style

Vighetto, Veronica, Luisa Racca, Marta Canta, Joana C. Matos, Bianca Dumontel, Maria C. Gonçalves, and Valentina Cauda. 2021. "Smart Shockwave Responsive Titania-Based Nanoparticles for Cancer Treatment" Pharmaceutics 13, no. 9: 1423. https://doi.org/10.3390/pharmaceutics13091423

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