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Firing up the Tumor Microenvironment with Nanoparticle-Based Therapies

by 1,†, 1,†, 1 and 1,2,*
1
The Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing 210008, China
2
Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210008, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Yogita Patil-Sen, Mohamed Elsawy and Thierry Vandamme
Pharmaceutics 2021, 13(9), 1338; https://doi.org/10.3390/pharmaceutics13091338
Received: 22 July 2021 / Revised: 14 August 2021 / Accepted: 23 August 2021 / Published: 26 August 2021
(This article belongs to the Special Issue Nanomaterials: Immunological Perspective)
Therapies mobilizing host immunity against cancer cells have profoundly improved prognosis of cancer patients. However, efficacy of immunotherapies depends on local immune conditions. The “cold” tumor, which is characterized by lacking inflamed T cells, is insensitive to immunotherapy. Current strategies of improving the “cold” tumor microenvironment are far from satisfying. Nanoparticle-based therapies provide novel inspiration in firing up the tumor microenvironment. In this review, we presented progress and limitations of conventional immunotherapies. Then, we enumerate advantages of nanoparticle-based therapies in remodeling the “cold” tumor microenvironment. Finally, we discuss the prospect of nanoparticle-based therapies in clinical application. View Full-Text
Keywords: nanoparticle; immunotherapy; tumor microenvironment; cancer vaccine; adoptive cell therapy nanoparticle; immunotherapy; tumor microenvironment; cancer vaccine; adoptive cell therapy
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MDPI and ACS Style

Pan, Y.; Song, X.; Wang, Y.; Wei, J. Firing up the Tumor Microenvironment with Nanoparticle-Based Therapies. Pharmaceutics 2021, 13, 1338. https://doi.org/10.3390/pharmaceutics13091338

AMA Style

Pan Y, Song X, Wang Y, Wei J. Firing up the Tumor Microenvironment with Nanoparticle-Based Therapies. Pharmaceutics. 2021; 13(9):1338. https://doi.org/10.3390/pharmaceutics13091338

Chicago/Turabian Style

Pan, Yunfeng, Xueru Song, Yue Wang, and Jia Wei. 2021. "Firing up the Tumor Microenvironment with Nanoparticle-Based Therapies" Pharmaceutics 13, no. 9: 1338. https://doi.org/10.3390/pharmaceutics13091338

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