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Article

Direct Powder Extrusion 3D Printing of Praziquantel to Overcome Neglected Disease Formulation Challenges in Paediatric Populations

1
IMT Mines Albi-Carmaux, CNRS UMR 5302, Centre RAPSODEE, Campus Jarlard, Université de Toulouse, CEDEX 09, 81013 Albi, France
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Oswaldo Cruz Foundation, Rua Sizenando Nabuco, 100 CEP 22.775-903, Rio de Janeiro 21040-900, Brazil
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Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK
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FabRx Ltd., 3 Romney Road, Ashford, Kent TN24 0RW, UK
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I+D Farma Group (GI-1645), Departamento de Farmacología, Farmacia y Tecnología Farmaceutica, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain
*
Authors to whom correspondence should be addressed.
Academic Editor: Juan José Torrado
Pharmaceutics 2021, 13(8), 1114; https://doi.org/10.3390/pharmaceutics13081114
Received: 29 June 2021 / Revised: 16 July 2021 / Accepted: 18 July 2021 / Published: 21 July 2021
For the last 40 years, praziquantel has been the standard treatment for schistosomiasis, a neglected parasitic disease affecting more than 250 million people worldwide. However, there is no suitable paediatric formulation on the market, leading to off-label use and the splitting of commercial tablets for adults. In this study, we use a recently available technology, direct powder extrusion (DPE) three-dimensional printing (3DP), to prepare paediatric Printlets™ (3D printed tablets) of amorphous solid dispersions of praziquantel with Kollidon® VA 64 and surfactants (Span™ 20 or Kolliphor® SLS). Printlets were successfully printed from both pellets and powders obtained from extrudates by hot melt extrusion (HME). In vitro dissolution studies showed a greater than four-fold increase in praziquantel release, due to the formation of amorphous solid dispersions. In vitro palatability data indicated that the printlets were in the range of praziquantel tolerability, highlighting the taste masking capabilities of this technology without the need for additional taste masking excipients. This work has demonstrated the possibility of 3D printing tablets using pellets or powder forms obtained by HME, avoiding the use of filaments in fused deposition modelling 3DP. Moreover, the main formulation hurdles of praziquantel, such as low drug solubility, inadequate taste, and high and variable dose requirements, can be overcome using this technology. View Full-Text
Keywords: 3D printing; 3D printed drug products; printing pharmaceuticals and medicines; personalized therapeutics; oral drug delivery systems and technologies; taste masking; translational pharmaceutics; material extrusion additive manufacturing; M3DIMAKER printer; pediatric treatments 3D printing; 3D printed drug products; printing pharmaceuticals and medicines; personalized therapeutics; oral drug delivery systems and technologies; taste masking; translational pharmaceutics; material extrusion additive manufacturing; M3DIMAKER printer; pediatric treatments
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MDPI and ACS Style

Boniatti, J.; Januskaite, P.; Fonseca, L.B.d.; Viçosa, A.L.; Amendoeira, F.C.; Tuleu, C.; Basit, A.W.; Goyanes, A.; Ré, M.-I. Direct Powder Extrusion 3D Printing of Praziquantel to Overcome Neglected Disease Formulation Challenges in Paediatric Populations. Pharmaceutics 2021, 13, 1114. https://doi.org/10.3390/pharmaceutics13081114

AMA Style

Boniatti J, Januskaite P, Fonseca LBd, Viçosa AL, Amendoeira FC, Tuleu C, Basit AW, Goyanes A, Ré M-I. Direct Powder Extrusion 3D Printing of Praziquantel to Overcome Neglected Disease Formulation Challenges in Paediatric Populations. Pharmaceutics. 2021; 13(8):1114. https://doi.org/10.3390/pharmaceutics13081114

Chicago/Turabian Style

Boniatti, Janine, Patricija Januskaite, Laís B. da Fonseca, Alessandra L. Viçosa, Fábio C. Amendoeira, Catherine Tuleu, Abdul W. Basit, Alvaro Goyanes, and Maria-Inês Ré. 2021. "Direct Powder Extrusion 3D Printing of Praziquantel to Overcome Neglected Disease Formulation Challenges in Paediatric Populations" Pharmaceutics 13, no. 8: 1114. https://doi.org/10.3390/pharmaceutics13081114

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