Next Article in Journal
Development of an Age-Appropriate Mini Orally Disintegrating Carvedilol Tablet with Paediatric Biopharmaceutical Considerations
Previous Article in Journal
Prediction of Drug Stability Using Deep Learning Approach: Case Study of Esomeprazole 40 mg Freeze-Dried Powder for Solution
Article

Undercover Toxic Ménage à Trois of Amylin, Copper (II) and Metformin in Human Embryonic Kidney Cells

1
Department of Medical Sciences and Public Health, University of Cagliari, 09042 Monserrato, Italy
2
Division of Biological and Environmental Sciences and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia
3
Core Labs, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia
4
Department of Biomedical Sciences, University of Cagliari, 09042 Monserrato, Italy
5
Consorzio Interuniversitario per lo Sviluppo dei Sistemi a Grande Interfase (CSGI), via della Lastruccia 3, 50019 Sesto Fiorentino, Italy
*
Authors to whom correspondence should be addressed.
Academic Editor: David Barlow
Pharmaceutics 2021, 13(6), 830; https://doi.org/10.3390/pharmaceutics13060830
Received: 30 April 2021 / Revised: 27 May 2021 / Accepted: 28 May 2021 / Published: 3 June 2021
In recent decades, type 2 diabetes complications have been correlated with amylin aggregation, copper homeostasis and metformin side effects. However, each factor was analyzed separately, and only in some rare cases copper/amylin or copper/metformin complexes were considered. We demonstrate for the first time that binary metformin/amylin and tertiary copper (II)/amylin/metformin complexes of high cellular toxicity are formed and lead to the formation of aggregated multi-level lamellar structures on the cell membrane. Considering the increased concentration of amylin, copper (II) and metformin in kidneys of T2DM patients, our findings on the toxicity of amylin and its adducts may be correlated with diabetic nephropathy development. View Full-Text
Keywords: diabetic nephropathy (DN); metformin; copper; human islet amyloid polypeptide (hIAPP); metal complexes diabetic nephropathy (DN); metformin; copper; human islet amyloid polypeptide (hIAPP); metal complexes
Show Figures

Figure 1

MDPI and ACS Style

Congiu, T.; Alghrably, M.; Emwas, A.-H.; Jaremko, L.; Lachowicz, J.I.; Piludu, M.; Piras, M.; Faa, G.; Pichiri, G.; Jaremko, M.; Coni, P. Undercover Toxic Ménage à Trois of Amylin, Copper (II) and Metformin in Human Embryonic Kidney Cells. Pharmaceutics 2021, 13, 830. https://doi.org/10.3390/pharmaceutics13060830

AMA Style

Congiu T, Alghrably M, Emwas A-H, Jaremko L, Lachowicz JI, Piludu M, Piras M, Faa G, Pichiri G, Jaremko M, Coni P. Undercover Toxic Ménage à Trois of Amylin, Copper (II) and Metformin in Human Embryonic Kidney Cells. Pharmaceutics. 2021; 13(6):830. https://doi.org/10.3390/pharmaceutics13060830

Chicago/Turabian Style

Congiu, Terenzio, Mawadda Alghrably, Abdul-Hamid Emwas, Lukasz Jaremko, Joanna I. Lachowicz, Marco Piludu, Monica Piras, Gavino Faa, Giuseppina Pichiri, Mariusz Jaremko, and Pierpaolo Coni. 2021. "Undercover Toxic Ménage à Trois of Amylin, Copper (II) and Metformin in Human Embryonic Kidney Cells" Pharmaceutics 13, no. 6: 830. https://doi.org/10.3390/pharmaceutics13060830

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop