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Review

Bacteria from Infectious Particles to Cell Based Anticancer Targeted Drug Delivery Systems

1
Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
2
Department of Microbiology and Immunology, Faculty of Pharmacy, Al-Azhar University, Cairo 11884, Egypt
3
Kayyali Chair for Pharmaceutical Industry, Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
4
Protein Research Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications, Alexandria 21934, Egypt
*
Author to whom correspondence should be addressed.
Academic Editors: Evgenia G. Korzhikova-Vlakh and Ivan Guryanov
Pharmaceutics 2021, 13(12), 1984; https://doi.org/10.3390/pharmaceutics13121984
Received: 3 August 2021 / Revised: 7 October 2021 / Accepted: 8 October 2021 / Published: 23 November 2021
(This article belongs to the Special Issue Advances in Delivering Protein and Peptide Therapeutics)
Bacterial ghosts (BGs) are empty cell envelopes of nonliving evacuated bacterial cells. They are free from their cytoplasmic contents; however, they sustain their cellular 3D morphology and antigenic structures, counting on bioadhesive properties. Lately, they have been tested as an advanced drug delivery system (DDS) for different materials like DNA, peptides, or drugs, either single components or combinations. Different studies have revealed that, BG DDS were paid the greatest attention in recent years. The current review explores the impact of BGs on the field of drug delivery and drug targeting. BGs have a varied area of applications, including vaccine and tumor therapy. Moreover, the use of BGs, their synthesis, their uniqueness as a delivery system and application principles in cancer are discussed. Furthermore, the safety issues of BGs and stability aspects of using ghost bacteria as delivery systems are discussed. Future perspective efforts that must be followed for this important system to continue to grow are important and promising. View Full-Text
Keywords: bacterial ghosts; drug delivery; protein; vaccine; therapeutics bacterial ghosts; drug delivery; protein; vaccine; therapeutics
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MDPI and ACS Style

Salem-Bekhit, M.M.; Youssof, A.M.E.; Alanazi, F.K.; Aleanizy, F.S.; Abdulaziz, A.; Taha, E.I.; Amara, A.A.A.F. Bacteria from Infectious Particles to Cell Based Anticancer Targeted Drug Delivery Systems. Pharmaceutics 2021, 13, 1984. https://doi.org/10.3390/pharmaceutics13121984

AMA Style

Salem-Bekhit MM, Youssof AME, Alanazi FK, Aleanizy FS, Abdulaziz A, Taha EI, Amara AAAF. Bacteria from Infectious Particles to Cell Based Anticancer Targeted Drug Delivery Systems. Pharmaceutics. 2021; 13(12):1984. https://doi.org/10.3390/pharmaceutics13121984

Chicago/Turabian Style

Salem-Bekhit, Mounir M., Abdullah M. E. Youssof, Fars K. Alanazi, Fadilah Sfouq Aleanizy, Alsuwyeh Abdulaziz, Ehab I. Taha, and Amro Abd Al Fattah Amara. 2021. "Bacteria from Infectious Particles to Cell Based Anticancer Targeted Drug Delivery Systems" Pharmaceutics 13, no. 12: 1984. https://doi.org/10.3390/pharmaceutics13121984

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