Neutrophils and Macrophages as Targets for Development of Nanotherapeutics in Inflammatory Diseases
Abstract
:1. Introduction
2. Inflammation Responses
2.1. Acute Inflammation
2.2. Chronic Inflammation
3. Immuno-Targeting by Nanoparticles
3.1. Nanoparticle Passive Targeting Immune Cells
3.2. Nanoparticle Active Targeting Immune Cells
4. Nanoparticles for Anti-Inflammation Therapy
4.1. Regulating Immune Cell Transmigration
4.2. Depleting Immune Cells Using Nanoparticles
4.3. Controlling Cellular Phenotypes
4.4. Regulating Cellular Functions
5. Restoring Immune Functions Using Nanoparticles
5.1. Restoring Neutrophil Functions
5.2. Reactivating Macrophage Immunity
6. Delivery of Nanotherapeutics via Leukocytes
6.1. In Situ Hijacking of Leukocytes to Deliver Nanotherapeutics
6.2. Nanoparticle-Laden Leukocytes In Vitro
7. Immunotoxicity in Leukocytes of Nanoparticle Uptake
8. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Su, Y.; Gao, J.; Kaur, P.; Wang, Z. Neutrophils and Macrophages as Targets for Development of Nanotherapeutics in Inflammatory Diseases. Pharmaceutics 2020, 12, 1222. https://doi.org/10.3390/pharmaceutics12121222
Su Y, Gao J, Kaur P, Wang Z. Neutrophils and Macrophages as Targets for Development of Nanotherapeutics in Inflammatory Diseases. Pharmaceutics. 2020; 12(12):1222. https://doi.org/10.3390/pharmaceutics12121222
Chicago/Turabian StyleSu, Yujie, Jin Gao, Puneet Kaur, and Zhenjia Wang. 2020. "Neutrophils and Macrophages as Targets for Development of Nanotherapeutics in Inflammatory Diseases" Pharmaceutics 12, no. 12: 1222. https://doi.org/10.3390/pharmaceutics12121222