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Article

Self-Assembled Polyester Dendrimer/Cellulose Nanofibril Hydrogels with Extraordinary Antibacterial Activity

1
KTH Royal Institute of Technology, School of Chemical Science and Engineering, Fiber and Polymer Technology, Teknikringen 56-58, SE-100 44 Stockholm, Sweden
2
KTH Royal Institute of Technology, Wallenberg Wood Science center. (WWSC), Teknikringen 56-58, SE-100 44 Stockholm, Sweden
*
Author to whom correspondence should be addressed.
These authors contributed to this work equally.
Pharmaceutics 2020, 12(12), 1139; https://doi.org/10.3390/pharmaceutics12121139
Received: 6 November 2020 / Revised: 19 November 2020 / Accepted: 20 November 2020 / Published: 25 November 2020
(This article belongs to the Special Issue Dendrimers and Dendritic Materials against Infectious Diseases)
Cationic dendrimers are intriguing materials that can be used as antibacterial materials; however, they display significant cytotoxicity towards diverse cell lines at high generations or high doses, which limits their applications in biomedical fields. In order to decrease the cytotoxicity, a series of biocompatible hybrid hydrogels based on cationic dendrimers and carboxylated cellulose nanofibrils were easily synthesized by non-covalent self-assembly under physiological conditions without external stimuli. The cationic dendrimers from generation 2 (G2) to generation 4 (G4) based on trimethylolpronane (TMP) and 2,2-bis (methylol)propionic acid (bis-MPA) were synthesized through fluoride promoted esterification chemistry (FPE chemistry). FTIR was used to show the presence of the cationic dendrimers within the hybrid hydrogels, and the distribution of the cationic dendrimers was even verified using elemental analysis of nitrogen content. The hybrid hydrogels formed from G3 and G4 showed 100% killing efficiency towards Escherichia coli (E. coli), Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa) with bacterial concentrations ranging from 105 CFU/mL to 107 CFU/mL. Remarkably, the hybrid hydrogels also showed good biocompatibility most probably due to the incorporation of the biocompatible CNFs that slowed down the release of the cationic dendrimers from the hybrid hydrogels, hence showing great promise as an antibacterial material for biomedical applications. View Full-Text
Keywords: cationic dendrimer; antibacterial materials; carboxylated cellulose nanofibrils; hybrid hydrogels cationic dendrimer; antibacterial materials; carboxylated cellulose nanofibrils; hybrid hydrogels
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MDPI and ACS Style

Fan, Y.; Namata, F.; Erlandsson, J.; Zhang, Y.; Wågberg, L.; Malkoch, M. Self-Assembled Polyester Dendrimer/Cellulose Nanofibril Hydrogels with Extraordinary Antibacterial Activity. Pharmaceutics 2020, 12, 1139. https://doi.org/10.3390/pharmaceutics12121139

AMA Style

Fan Y, Namata F, Erlandsson J, Zhang Y, Wågberg L, Malkoch M. Self-Assembled Polyester Dendrimer/Cellulose Nanofibril Hydrogels with Extraordinary Antibacterial Activity. Pharmaceutics. 2020; 12(12):1139. https://doi.org/10.3390/pharmaceutics12121139

Chicago/Turabian Style

Fan, Yanmiao, Faridah Namata, Johan Erlandsson, Yuning Zhang, Lars Wågberg, and Michael Malkoch. 2020. "Self-Assembled Polyester Dendrimer/Cellulose Nanofibril Hydrogels with Extraordinary Antibacterial Activity" Pharmaceutics 12, no. 12: 1139. https://doi.org/10.3390/pharmaceutics12121139

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