Next Article in Journal / Special Issue
pH-Responsive i-motif Conjugated Hyaluronic Acid/Polyethylenimine Complexes for Drug Delivery Systems
Previous Article in Journal
Established and Emerging Strategies for Drug Delivery Across the Blood-Brain Barrier in Brain Cancer
Previous Article in Special Issue
Developing Body-Components-Based Theranostic Nanoparticles for Targeting Ovarian Cancer
Open AccessArticle

Hyaluronic Acid Nanocapsules as a Platform for Needle-Free Vaccination

1
Departamento de Farmacia, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Santiago 7820436, Chile
2
Centro de Investigación en Nanotecnología y Materiales Avanzados “CIEN-UC”, Pontificia Universidad Católica de Chile, Santiago 7820436, Chile
3
Department of Chemical and Biomolecular Engineering, University of Notre Dame, 340E McCourtney Hall, Notre Dame, IN 46556, USA
*
Author to whom correspondence should be addressed.
Pharmaceutics 2019, 11(5), 246; https://doi.org/10.3390/pharmaceutics11050246
Received: 2 May 2019 / Revised: 23 May 2019 / Accepted: 23 May 2019 / Published: 26 May 2019
(This article belongs to the Special Issue Hyaluronic Acid for Biomedical Applications)
Vaccination faces many challenges nowadays, and among them the use of adjuvant molecules and needle-free administration are some of the most demanding. The combination of transcutaneous vaccination and nanomedicine through a rationally designed new-formulation could be the solution to this problem. This study focuses on this rational design. For this purpose, new hyaluronic acid nanocapsules (HA-NCs) have been developed. This new formulation has an oily nucleus with immunoadjuvant properties (due to α tocopherol) and a shell made of hyaluronic acid (HA) and decorated with ovalbumin (OVA) as the model antigen. The resulting nanocapsules are smaller than 100 nm, have a negative superficial charge and have a population that is homogeneously distributed. The systems show high colloidal stability in storage and physiological conditions and high OVA association without losing their integrity. The elevated interaction of the novel formulation with the immune system was demonstrated through complement activation and macrophage viability studies. Ex vivo studies using a pig skin model show the ability of these novel nanocapsules to penetrate and retain OVA in higher quantities in skin when compared to this antigen in the control solution. Due to these findings, HA-NCs are an interesting platform for needle-free vaccination. View Full-Text
Keywords: nanomedicine; vaccine; nanovaccine transcutaneous immunization; nanocapsules; hyaluronic acid; needle-free; antigen delivery; skin delivery nanomedicine; vaccine; nanovaccine transcutaneous immunization; nanocapsules; hyaluronic acid; needle-free; antigen delivery; skin delivery
Show Figures

Graphical abstract

MDPI and ACS Style

Bussio, J.I.; Molina-Perea, C.; González-Aramundiz, J.V. Hyaluronic Acid Nanocapsules as a Platform for Needle-Free Vaccination. Pharmaceutics 2019, 11, 246.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop