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Open AccessArticle

A Functional Wound Dressing as a Potential Treatment for Cutaneous Leishmaniasis

1
Programa de Pós-Graduação em Nanotecnologia Farmacêutica (PPgNANOFARMA), Universidade Federal do Rio Grande do Norte (UFRN), Nata/RN 59012-570, Brazil
2
Faculdade de Farmácia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro/RJ 21941-902, Brazil
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Instituto de Física de São Carlos, Universidade de São Paulo (USP), São Carlos/SP 13563-120, Brazil
4
Departamento do Medicamento, Universidade Federal da Bahia (UFBA), Salvador/BA 40170-115, Brazil
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Faculdade de Farmácia, Universidade Federal do Rio Grande do Norte (UFRN), Nata/RN 59012-570, Brazil
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Departamento de Fármacos e Medicamentos, Universidade Estadual Paulista (UNESP), Araraquara/SP 14800-903, Brazil
7
Laboratório de Sistemas Dispersos (LaSiD), Departamento de Farmácia, Universidade Federal do Rio Grande do Norte (UFRN), Rua General Gustavo Cordeiro de Farias s/n, Petrópolis, Nata/RN 59012-570, Brazil
*
Author to whom correspondence should be addressed.
Pharmaceutics 2019, 11(5), 200; https://doi.org/10.3390/pharmaceutics11050200
Received: 18 February 2019 / Revised: 18 March 2019 / Accepted: 21 March 2019 / Published: 1 May 2019
(This article belongs to the Special Issue Antifungal and Antiparasitic Drug Delivery)
Cutaneous leishmaniasis (CL) is a parasitic disease characterized by progressive skin sores. Currently, treatments for CL are limited to parenteral administration of the drug, which presents severe adverse effects and low cure rates. Therefore, this study aimed to develop poly(vinyl-alcohol) (PVA) hydrogels containing Amphotericin B (AmB) intended for topical treatment of CL. Hydrogels were evaluated in vitro for their potential to eliminate promastigote forms of Leishmania spp., to prevent secondary infections, to maintain appropriate healing conditions, and to offer suitable biocompatibility. AmB was incorporated into the system in its non-crystalline state, allowing it to swell more and faster than the system without the drug. Furthermore, the AmB release profile showed a continuous and controlled behavior following Higuchi´s kinetic model. AmB-loaded-PVA-hydrogels (PVA–AmB) also showed efficient antifungal and leishmanicidal activity, no cytotoxic potential for VERO cells, microbial impermeability and water vapor permeability compatible with the healthy skin’s physiological needs. Indeed, these results revealed the potential of PVA–AmB to prevent secondary infections and to maintain a favorable environment for the healing process. Hence, these results suggest that PVA–AmB could be a suitable and efficient new therapeutic approach for the topical treatment of CL. View Full-Text
Keywords: Amphotericin B; cutaneous leishmaniasis; hydrogel; wound dressing; controlled release Amphotericin B; cutaneous leishmaniasis; hydrogel; wound dressing; controlled release
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MDPI and ACS Style

Alexandrino-Junior, F.; Silva, K.G.H.; Freire, M.C.L.C.; Lione, V.O.F.; Cardoso, E.A.; Marcelino, H.R.; Genre, J.; Oliveira, A.G.; Egito, E.S.T. A Functional Wound Dressing as a Potential Treatment for Cutaneous Leishmaniasis. Pharmaceutics 2019, 11, 200.

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