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Pharmaceutics 2018, 10(4), 224;

Collagen-Polyvinyl Alcohol-Indomethacin Biohybrid Matrices as Wound Dressings

Department of Collagen, Division Leather and Footwear Research Institute, National Research and Development Institute for Textile and Leather, 031215 Bucharest, Romania
Center of Surface Science and Nanotechnology, University Politehnica of Bucharest, 060042 Splaiul Independentei 313, Romania
Department of Physical and Colloidal Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy “Carol Davila”, 20956 Bucharest, Romania
Department of Clinical Laboratory and Food Safety, Faculty of Pharmacy, University of Medicine and Pharmacy “Carol Davila”, 020956 Bucharest, Romania
Academy of Romanian Scientists, 010071 Bucharest, Romania
Author to whom correspondence should be addressed.
Received: 26 September 2018 / Revised: 26 October 2018 / Accepted: 7 November 2018 / Published: 9 November 2018
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The aim of this study is to design, develop and evaluate new biohybrid sponges based on polymers (collagen and polyvinyl alcohol) with and without indomethacin as anti-inflammatory drug model to be used for tissue regeneration in wound healing. Type I fibrillar collagen in the form of a gel and different concentrations of polyvinyl alcohol were mixed together to prepare composite gels. Both control samples, without indomethacin and with indomethacin, were obtained. All samples were crosslinked with glutaraldehyde. By freeze-drying of hydrogels, the spongious forms (matrices) were obtained. The matrices were characterized by FT-IR spectroscopy, scanning electron microscopy (SEM), water absorption, enzymatic degradation and in vitro indomethacin release. The pharmacological effect of the spongious biohybrid matrices was determined on an experimental model of burns induced to Wistar rats. The SEM images showed a porous structure with interconnected pores. Collagen sponges present a structure with pore sizes between 20 and 200 µm, which became more and more compact with polyvinyl alcohol addition. The FT-IR showed interactions between collagen and polyvinyl alcohol. The enzymatic degradation indicated that the most stable matrix is the one with the ratio 75:25 of collagen:polyvinyl alcohol (ACI75), the other ones being degradable in time. The kinetic data of indomethacin release from matrices were fitted with different kinetic models and highlighted a biphasic release of the drug. Such kinetic profiles are targeted in skin wound healing for which important aspects are impaired inflammation and local pain. The treatment with sponges associated with anti-inflammatory drug had beneficial effects on the healing process in experimentally induced burns compared to the corresponding matrices without indomethacin and the classical treated control group. View Full-Text
Keywords: collagen; indomethacin; wound dressing collagen; indomethacin; wound dressing

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Marin, Ș.; Albu Kaya, M.G.; Ghica, M.V.; Dinu-Pîrvu, C.; Popa, L.; Udeanu, D.I.; Mihai, G.; Enachescu, M. Collagen-Polyvinyl Alcohol-Indomethacin Biohybrid Matrices as Wound Dressings. Pharmaceutics 2018, 10, 224.

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