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Porous Inorganic Carriers Based on Silica, Calcium Carbonate and Calcium Phosphate for Controlled/Modulated Drug Delivery: Fresh Outlook and Future Perspectives

1
Department of Nanophotonics and Metamaterials, Saint Petersburg National Research University of Information Technologies, ITMO University, 197101 St. Petersburg, Russia
2
Research School of Chemical and Biomedical Engineering, National Research Tomsk Polytechnic University, Lenin Avenue 30, 634050 Tomsk, Russia
3
Department of Micro- and Nano-Encapsulation, First Pavlov State Medical University of St. Petersburg, Lev Tolstoy str. 6/8, 197022 Saint-Petersburg, Russia
*
Authors to whom correspondence should be addressed.
Pharmaceutics 2018, 10(4), 167; https://doi.org/10.3390/pharmaceutics10040167
Received: 16 August 2018 / Revised: 12 September 2018 / Accepted: 19 September 2018 / Published: 25 September 2018
(This article belongs to the Special Issue Porous Inorganic Drug Delivery Systems)
Porous inorganic nanostructured materials are widely used nowadays as drug delivery carriers due to their adventurous features: suitable architecture, large surface area and stability in the biological fluids. Among the different types of inorganic porous materials, silica, calcium carbonate, and calcium phosphate have received significant attention in the last decade. The use of porous inorganic materials as drug carriers for cancer therapy, gene delivery etc. has the potential to improve the life expectancy of the patients affected by the disease. The main goal of this review is to provide general information on the current state of the art of synthesis of the inorganic porous particles based on silica, calcium carbonate and calcium phosphate. Special focus is dedicated to the loading capacity, controllable release of drugs under internal biological stimuli (e.g., pH, redox, enzymes) and external noninvasive stimuli (e.g., light, magnetic field, and ultrasound). Moreover, the diverse compounds to deliver with silica, calcium carbonate and calcium phosphate particles, ranging from the commercial drugs to genetic materials are also discussed. View Full-Text
Keywords: drug delivery systems; silica-based particles; calcium carbonate; calcium phosphate; in vitro and in vivo delivery; drug loading drug delivery systems; silica-based particles; calcium carbonate; calcium phosphate; in vitro and in vivo delivery; drug loading
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MDPI and ACS Style

Trofimov, A.D.; Ivanova, A.A.; Zyuzin, M.V.; Timin, A.S. Porous Inorganic Carriers Based on Silica, Calcium Carbonate and Calcium Phosphate for Controlled/Modulated Drug Delivery: Fresh Outlook and Future Perspectives. Pharmaceutics 2018, 10, 167.

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