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Pharmaceutics 2018, 10(3), 115; https://doi.org/10.3390/pharmaceutics10030115

Fast Dissolving of Ferulic Acid via Electrospun Ternary Amorphous Composites Produced by a Coaxial Process

1
School of Chemistry and Chemical Engineering, Hubei Polytechnic University, Huangshi 435003, China
2
Hubei Key Laboratory of Mine Environmental Pollution Control and Remediation, Hubei Polytechnic University, Huangshi 435003, China
3
School of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China
*
Authors to whom correspondence should be addressed.
Received: 30 May 2018 / Revised: 23 July 2018 / Accepted: 24 July 2018 / Published: 2 August 2018
(This article belongs to the Special Issue Electrospun and Electrosprayed Formulations for Drug Delivery)
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Abstract

Enhancing the dissolution of insoluble active ingredients comprises one of the most important issues in the pharmaceutical and biomaterial fields. Here, a third generation solid dispersion (3rd SD) of ferulic acid was designed and fabricated by a modified coaxial electrospinning process. A traditional second generation SD (2nd SD) was also prepared by common one-fluid blending electrospinning and was used as a control. With poly(vinyl alcohol) as the fiber matrix and polyvinylpyrrolidone K10 as an additive in the 3rd SDs, the two electrospinning processes were investigated. The prepared 2nd and 3rd SDs were subjected to a series of characterizations, including X-ray diffraction (XRD), scanning electron microscope (SEM), hydrophilicity and in vitro drug dissolving experiments. The results demonstrate that both SDs were monolithic nanocomposites and that the drugs were amorphously distributed within the matrix. However, the 3rd SDs had better morphology with smaller size, narrower size distribution, and smaller water contact angles than the 2nd SDs. Dissolution tests verified that the 3rd SDs could release their loaded cargoes within 60 s, which was over three times faster than the 2nd SDs. Therefore, a combined strategy based on the modified coaxial electrospinning and the logical selections of drug carriers is demonstrated for creating advanced biomaterials. View Full-Text
Keywords: amorphous composite; coaxial electrospinning; fast dissolution; insoluble drug; solid dispersion amorphous composite; coaxial electrospinning; fast dissolution; insoluble drug; solid dispersion
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Huang, W.; Yang, Y.; Zhao, B.; Liang, G.; Liu, S.; Liu, X.-L.; Yu, D.-G. Fast Dissolving of Ferulic Acid via Electrospun Ternary Amorphous Composites Produced by a Coaxial Process. Pharmaceutics 2018, 10, 115.

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