Next Article in Journal
Acknowledgement to Reviewers of Pharmaceutics in 2017
Next Article in Special Issue
Feasibility of Using Gluconolactone, Trehalose and Hydroxy-Propyl Gamma Cyclodextrin to Enhance Bendroflumethiazide Dissolution Using Lyophilisation and Physical Mixing Techniques
Previous Article in Journal
Regulation of Hepatic UGT2B15 by Methylation in Adults of Asian Descent
Article Menu
Issue 1 (March) cover image

Export Article

Open AccessArticle
Pharmaceutics 2018, 10(1), 7; https://doi.org/10.3390/pharmaceutics10010007

Curcumin-Artemisinin Coamorphous Solid: Xenograft Model Preclinical Study

1
School of Chemistry, University of Hyderabad, Hyderabad 500 046, India
2
Technology Business Incubator, University of Hyderabad, Hyderabad 500 046, India
3
Virchow Biotech Pvt. Ltd., Animal House Facility, Hyderabad 500 055, India
4
Council of Scientific and Industrial Research National Chemical Laboratory, Pune 411 008, India
*
Author to whom correspondence should be addressed.
Received: 29 November 2017 / Revised: 27 December 2017 / Accepted: 4 January 2018 / Published: 9 January 2018
(This article belongs to the Special Issue Dissolution Enhancement of Poorly Soluble Drugs)
Full-Text   |   PDF [4180 KB, uploaded 9 January 2018]   |  

Abstract

Curcumin is a natural compound present in Indian spice turmeric. It has diverse pharmacological action but low oral solubility and bioavailability continue to limit its use as a drug. With the aim of improving the bioavailability of Curcumin (CUR), we evaluated Curcumin-Pyrogallol (CUR-PYR) cocrystal and Curcumin-Artemisinin (CUR-ART) coamorphous solid. Both of these solid forms exhibited superior dissolution and pharmacokinetic behavior compared to pure CUR, which is practically insoluble in water. CUR-ART coamorphous solid showed two fold higher bioavailability than CUR-PYR cocrystal (at 200 mg/kg oral dose). Moreover, in simulated gastric and intestinal fluids (SGF and SIF), CUR-ART is stable up to 3 and 12 h, respectively. In addition, CUR-PYR and CUR-ART showed no adverse effects in toxicology studies (10 times higher dose at 2000 mg/kg). CUR-ART showed higher therapeutic effect and inhibited approximately 62% of tumor growth at 100 mg/kg oral dosage of CUR in xenograft models, which is equal to the positive control drug, doxorubicin (2 mg/kg) by i.v. administration. View Full-Text
Keywords: curcumin; artemisinin; coamorphous; cocrystal; stability; bioavailability; xenograft curcumin; artemisinin; coamorphous; cocrystal; stability; bioavailability; xenograft
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Mannava, M.K.C.; Suresh, K.; Kumar Bommaka, M.; Bhavani Konga, D.; Nangia, A. Curcumin-Artemisinin Coamorphous Solid: Xenograft Model Preclinical Study. Pharmaceutics 2018, 10, 7.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Pharmaceutics EISSN 1999-4923 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top