Next Article in Journal
The Broad Host Range and Genetic Diversity of Mammalian and Avian Astroviruses
Previous Article in Journal
Cowpox virus: What’s in a Name?
Article Menu
Issue 5 (May) cover image

Export Article

Open AccessReview
Viruses 2017, 9(5), 100;

Regulated Entry of Hepatitis C Virus into Hepatocytes

Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China
Yunnan Institute of Digestive Disease, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, China
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Academic Editor: Jens H. Kuhn
Received: 21 March 2017 / Revised: 24 April 2017 / Accepted: 2 May 2017 / Published: 9 May 2017
(This article belongs to the Section Animal Viruses)
Full-Text   |   PDF [752 KB, uploaded 9 May 2017]   |  


Hepatitis C virus (HCV) is a model for the study of virus–host interaction and host cell responses to infection. Virus entry into hepatocytes is the first step in the HCV life cycle, and this process requires multiple receptors working together. The scavenger receptor class B type I (SR-BI) and claudin-1 (CLDN1), together with human cluster of differentiation (CD) 81 and occludin (OCLN), constitute the minimal set of HCV entry receptors. Nevertheless, HCV entry is a complex process involving multiple host signaling pathways that form a systematic regulatory network; this network is centrally controlled by upstream regulators epidermal growth factor receptor (EGFR) and transforming growth factor β receptor (TGFβ-R). Further feedback regulation and cell-to-cell spread of the virus contribute to the chronic maintenance of HCV infection. A comprehensive and accurate disclosure of this critical process should provide insights into the viral entry mechanism, and offer new strategies for treatment regimens and targets for HCV therapeutics. View Full-Text
Keywords: hepatitis C virus; cell entry; regulation; signaling; receptor hepatitis C virus; cell entry; regulation; signaling; receptor

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Miao, Z.; Xie, Z.; Miao, J.; Ran, J.; Feng, Y.; Xia, X. Regulated Entry of Hepatitis C Virus into Hepatocytes. Viruses 2017, 9, 100.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top