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Impaired Expression of Cytokines as a Result of Viral Infections with an Emphasis on Small Ruminant Lentivirus Infection in Goats

Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, ul. Postepu 36A, 05-552 Magdalenka, Poland
Laboratory of Veterinary Epidemiology and Economics, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, ul. Nowoursynowska 166, 02-787 Warszawa, Poland
Author to whom correspondence should be addressed.
Academic Editor: Alexander Ploss
Viruses 2016, 8(7), 186;
Received: 8 April 2016 / Revised: 11 June 2016 / Accepted: 30 June 2016 / Published: 5 July 2016
(This article belongs to the Section Animal Viruses)
Knowing about the genes involved in immunity, and being able to identify the factors influencing their expressions, helps in gaining awareness of the immune processes. The qPCR method is a useful gene expression analysis tool, but studies on immune system genes are still limited, especially on the caprine immune system. Caprine arthritis encephalitis, a disease caused by small ruminant lentivirus (SRLV), causes economic losses in goat breeding, and there is no therapy against SRLV. The results of studies on vaccines against other viruses are promising. Moreover, the Marker-Assisted Selection strategy against SRLV is possible, as has been shown in sheep breeding. However, there are still many gaps in our knowledge on the caprine immune response to infection. All types of cytokines play pivotal roles in immunity, and SRLV infection influences the expression of many cytokines in different types of cells. This information encouraged the authors to examine the results of studies conducted on SRLV and other viral infections, with an emphasis on the expression of cytokine genes. This review attempts to summarize the results of studies on the expression of cytokines in the context of the SRLV infection. View Full-Text
Keywords: goat; SRLV; gene expression; cytokine goat; SRLV; gene expression; cytokine
MDPI and ACS Style

Jarczak, J.; Kaba, J.; Reczyńska, D.; Bagnicka, E. Impaired Expression of Cytokines as a Result of Viral Infections with an Emphasis on Small Ruminant Lentivirus Infection in Goats. Viruses 2016, 8, 186.

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