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Viruses 2015, 7(8), 4756-4771;

The Antiviral Effect of Baicalin on Enterovirus 71 In Vitro

Department of Clinical Laboratory, Huai'an Hospital Affiliated of Xuzhou Medical College, 62 Huaihai south road, Huai'an, Jiangsu 223300, China
Department of Endocrinology, Huai'an First Affliated Hospital of Nanjing Medical University, 6 Beijing west road, Huai'an, Jiangsu 223300, China
Department of Clinical Laboratory, the Fourth People's Hospital of Huai'an, 128 Yanan east road, Huai'an, Jiangsu 223300, China
Department of Clinical Laboratory, the Third Affiliated Hospital of Soochow University, 185 Juqian street, Changzhou, Jiangsu 213003, China
These author contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Curt Hagedorn
Received: 19 April 2015 / Revised: 24 July 2015 / Accepted: 10 August 2015 / Published: 19 August 2015
(This article belongs to the Section Antivirals & Vaccines)
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Baicalin is a flavonoid compound extracted from Scutellaria roots that has been reported to possess antibacterial, anti-inflammatory, and antiviral activities. However, the antiviral effect of baicalin on enterovirus 71 (EV71) is still unknown. In this study, we found that baicalin showed inhibitory activity on EV71 infection and was independent of direct virucidal or prophylactic effect and inhibitory viral absorption. The expressions of EV71/3D mRNA and polymerase were significantly blocked by baicalin treatment at early stages of EV71 infection. In addition, baicalin could decrease the expressions of FasL and caspase-3, as well as inhibit the apoptosis of EV71-infected human embryonal rhabdomyosarcoma (RD) cells. Altogether, these results indicate that baicalin exhibits potent antiviral effect on EV71 infection, probably through inhibiting EV71/3D polymerase expression and Fas/FasL signaling pathways. View Full-Text
Keywords: baicalin; enterovirus 71; 3D polymerase; apoptosis baicalin; enterovirus 71; 3D polymerase; apoptosis

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Li, X.; Liu, Y.; Wu, T.; Jin, Y.; Cheng, J.; Wan, C.; Qian, W.; Xing, F.; Shi, W. The Antiviral Effect of Baicalin on Enterovirus 71 In Vitro. Viruses 2015, 7, 4756-4771.

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