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Viroporins: Structures and functions beyond cell membrane permeabilization
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Emerging Roles of Viroporins Encoded by DNA Viruses: Novel Targets for Antivirals?

School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK
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Academic Editors: José Luis Nieva and Luis Carrasco
Viruses 2015, 7(10), 5375-5387; https://doi.org/10.3390/v7102880
Received: 20 August 2015 / Revised: 2 October 2015 / Accepted: 12 October 2015 / Published: 16 October 2015
(This article belongs to the Special Issue Viroporins)
Studies have highlighted the essential nature of a group of small, highly hydrophobic, membrane embedded, channel-forming proteins in the life cycles of a growing number of RNA viruses. These viroporins mediate the flow of ions and a range of solutes across cellular membranes and are necessary for manipulating a myriad of host processes. As such they contribute to all stages of the virus life cycle. Recent discoveries have identified proteins encoded by the small DNA tumor viruses that display a number of viroporin like properties. This review article summarizes the recent developments in our understanding of these novel viroporins; describes their roles in the virus life cycles and in pathogenesis and speculates on their potential as targets for anti-viral therapeutic intervention. View Full-Text
Keywords: DNA virus; viroporin; papillomavirus; polyomavirus DNA virus; viroporin; papillomavirus; polyomavirus
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Royle, J.; Dobson, S.J.; Müller, M.; Macdonald, A. Emerging Roles of Viroporins Encoded by DNA Viruses: Novel Targets for Antivirals? Viruses 2015, 7, 5375-5387.

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