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Make Yourself at Home: Viral Hijacking of the PI3K/Akt Signaling Pathway

Universitätsklinikum Düsseldorf, Institut für Virologie, Universitätsstraße 1, Düsseldorf 40225, Germany
Author to whom correspondence should be addressed.
Viruses 2013, 5(12), 3192-3212;
Received: 29 October 2013 / Revised: 3 December 2013 / Accepted: 5 December 2013 / Published: 16 December 2013
(This article belongs to the Section Animal Viruses)
PDF [657 KB, uploaded 12 May 2015]


As viruses do not possess genes encoding for proteins required for translation, energy metabolism or membrane biosynthesis, they are classified as obligatory intracellular parasites that depend on a host cell to replicate. This genome limitation forces them to gain control over cellular processes to ensure their successful propagation. A diverse spectrum of virally encoded proteins tackling a broad spectrum of cellular pathways during most steps of the viral life cycle ranging from the host cell entry to viral protein translation has evolved. Since the host cell PI3K/Akt signaling pathway plays a critical regulatory role in many cellular processes including RNA processing, translation, autophagy and apoptosis, many viruses, in widely varying ways, target it. This review focuses on a number of remarkable examples of viral strategies, which exploit the PI3K/Akt signaling pathway for effective viral replication. View Full-Text
Keywords: PI3K/Akt signaling; viral entry; alternative splicing; mTOR; apoptosis PI3K/Akt signaling; viral entry; alternative splicing; mTOR; apoptosis

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Diehl, N.; Schaal, H. Make Yourself at Home: Viral Hijacking of the PI3K/Akt Signaling Pathway. Viruses 2013, 5, 3192-3212.

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