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Viruses 2012, 4(8), 1258-1263;

The Role of Equine Herpesvirus Type 4 Glycoprotein K in Virus Replication

Department of Virology, Faculty of Veterinary Medicine, Zagazig University, Egypt
Current address: Institute of Virology, Department of Veterinary Medicine, Free University of Berlin, Philippstrasse 13, Haus 18, 10115 Berlin, Germany.
Author to whom correspondence should be addressed.
Received: 29 June 2012 / Revised: 31 July 2012 / Accepted: 3 August 2012 / Published: 7 August 2012
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Equine herpesvirus 4 (EHV-4) is an important equine pathogen that causes respiratory tract disease among horses worldwide. Glycoprotein K (gK) homologues have been identified in several alphaherpesviruses as a major player in virus entry, replication, and spread. In the present study, EHV-4 gK-deletion mutant has been generated by using bacterial artificial chromosome technology and Red mutagenesis to investigate the role of gK in EHV-4 replication. Our findings reported here show that gK is essential for virus replication in vitro and that the gK-negative strain was not able to be reconstituted in equine cells. It is noteworthy that these findings agree with the previously published study describing gK deletion in other alphaherpesviruses. View Full-Text
Keywords: EHV-4; BAC; gK EHV-4; BAC; gK

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Azab, W.; El-Sheikh, A. The Role of Equine Herpesvirus Type 4 Glycoprotein K in Virus Replication. Viruses 2012, 4, 1258-1263.

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