Next Article in Journal
Exploratory Spatial Analysis of in vitro Respiratory Syncytial Virus Co-infections
Previous Article in Journal
Monkeypox Virus Infections in Small Animal Models for Evaluation of Anti-Poxvirus Agents
Open AccessCommentary

Modeling the HIV-1 Intasome: A Prototype View of the Target of Integrase Inhibitors

Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Author to whom correspondence should be addressed.
Viruses 2010, 2(12), 2777-2781;
Received: 18 November 2010 / Revised: 4 December 2010 / Accepted: 6 December 2010 / Published: 21 December 2010
(This article belongs to the Section Editorial)
The HIV-1 integrase enzyme is essential for integrating the viral DNA into the host chromosome. Infection is aborted in the absence of integration, making integrase an attractive antiviral target. Recently approved inhibitors of integrase bind tightly to integrase assembled in a nucleoprotein complex with the viral DNA ends (intasome), but have only low affinity for free integrase. High-resolution structures of HIV-1 intasomes are therefore required to understand the detailed mechanisms of inhibition and resistance. Although the structure of the HIV-1 intasome has not yet been determined, the structure of the related prototype foamy virus (PFV) intasome was recently solved. A new study [1] exploits the PFV structure to model the HIV-1 intasome. The model provides the most reliable picture to date of the active site region of the HIV-1 intasome and is an important advance in studies of inhibition of this essential HIV-1 enzyme.
Keywords: HIV-1; integrase; intasome HIV-1; integrase; intasome
MDPI and ACS Style

Yin, Z.; Craigie, R. Modeling the HIV-1 Intasome: A Prototype View of the Target of Integrase Inhibitors. Viruses 2010, 2, 2777-2781.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

Only visits after 24 November 2015 are recorded.
Search more from Scilit
Back to TopTop