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Volume 15
Issue 3
10.3390/v15030618
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Article

Surfing the Waves: Differences in Hospitalised COVID-19 Patients across 4 Variant Waves in a Belgian University Hospital

by
Lucie Seyler
1,*,
Els Van Nedervelde
1,
Diederik De Cock
2,
Claudia Mann
1,
Karen Pien
3,
Sabine D. Allard
1 and
Thomas Demuyser
4,5
1
Infectiology Research Group, Infectious Diseases Department, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel (VUB), 1090 Brussels, Belgium
2
Biostatistics and Medical Informatics Research Group, Department of Public Health, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel (VUB), 1090 Brussels, Belgium
3
Medical Registration, Universitair Ziekenhuis Brussel, 1090 Brussels, Belgium
4
Department of Microbiology and Infection Control, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel (VUB), 1090 Brussels, Belgium
5
AIMS Lab, Center for Neurosciences, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel (VUB), 1090 Brussels, Belgium
*
Author to whom correspondence should be addressed.
Viruses 2023, 15(3), 618; https://doi.org/10.3390/v15030618
Submission received: 27 January 2023 / Revised: 14 February 2023 / Accepted: 17 February 2023 / Published: 23 February 2023
(This article belongs to the Special Issue SARS-CoV-2 Research in Belgium)
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Abstract

The unprecedented COVID-19 pandemic took the form of successive variant waves, spreading across the globe. We wanted to investigate any shift in hospitalised patients’ profiles throughout the pandemic. For this study, we used a registry that collected data automatically from electronic patient health records. We compared clinical data and severity scores, using the National Institute of Health (NIH) severity scores, from all patients admitted for COVID-19 during four SARS-CoV-2 variant waves. Our study concluded that patients hospitalised for COVID-19 showed very different profiles across the four variant waves in Belgium. Patients were younger during the Alpha and Delta waves and frailer during the Omicron period. ‘Critical’ patients according to the NIH criteria formed the largest fraction among the Alpha wave patients (47.7%), while ‘severe’ patients formed the largest fraction among Omicron patients (61.6%). We discussed host factors, vaccination status, and other confounders to put this into perspective. High-quality real-life data remain crucial to inform stakeholders and policymakers that shifts in patients’ clinical profiles have an impact on clinical practice.
Keywords: COVID-19; SARS-CoV-2; pandemic; inpatients; disease severity; registry data COVID-19; SARS-CoV-2; pandemic; inpatients; disease severity; registry data

Share and Cite

MDPI and ACS Style

Seyler, L.; Van Nedervelde, E.; De Cock, D.; Mann, C.; Pien, K.; Allard, S.D.; Demuyser, T. Surfing the Waves: Differences in Hospitalised COVID-19 Patients across 4 Variant Waves in a Belgian University Hospital. Viruses 2023, 15, 618. https://doi.org/10.3390/v15030618

AMA Style

Seyler L, Van Nedervelde E, De Cock D, Mann C, Pien K, Allard SD, Demuyser T. Surfing the Waves: Differences in Hospitalised COVID-19 Patients across 4 Variant Waves in a Belgian University Hospital. Viruses. 2023; 15(3):618. https://doi.org/10.3390/v15030618

Chicago/Turabian Style

Seyler, Lucie, Els Van Nedervelde, Diederik De Cock, Claudia Mann, Karen Pien, Sabine D. Allard, and Thomas Demuyser. 2023. "Surfing the Waves: Differences in Hospitalised COVID-19 Patients across 4 Variant Waves in a Belgian University Hospital" Viruses 15, no. 3: 618. https://doi.org/10.3390/v15030618

APA Style

Seyler, L., Van Nedervelde, E., De Cock, D., Mann, C., Pien, K., Allard, S. D., & Demuyser, T. (2023). Surfing the Waves: Differences in Hospitalised COVID-19 Patients across 4 Variant Waves in a Belgian University Hospital. Viruses, 15(3), 618. https://doi.org/10.3390/v15030618

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