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Article

Spatial and Temporal Dynamics and Molecular Evolution of Tula orthohantavirus in German Vole Populations

1
Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut (FLI), Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems, Germany
2
Animal Ecology, Institute of Biochemistry and Biology, University of Potsdam, 14469 Potsdam, Germany
3
Institute of Ecology and Evolution, University of Bern, 3012 Bern, Switzerland
4
Institute for Plant Protection in Horticulture and Forests, Julius Kühn-Institute (JKI), 48161 Münster, Germany
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Richard J. Kuhn
Viruses 2021, 13(6), 1132; https://doi.org/10.3390/v13061132
Received: 31 March 2021 / Revised: 21 May 2021 / Accepted: 3 June 2021 / Published: 11 June 2021
(This article belongs to the Special Issue Rodent-Borne Viruses)
Tula orthohantavirus (TULV) is a rodent-borne hantavirus with broad geographical distribution in Europe. Its major reservoir is the common vole (Microtus arvalis), but TULV has also been detected in closely related vole species. Given the large distributional range and high amplitude population dynamics of common voles, this host–pathogen complex presents an ideal system to study the complex mechanisms of pathogen transmission in a wild rodent reservoir. We investigated the dynamics of TULV prevalence and the subsequent potential effects on the molecular evolution of TULV in common voles of the Central evolutionary lineage. Rodents were trapped for three years in four regions of Germany and samples were analyzed for the presence of TULV-reactive antibodies and TULV RNA with subsequent sequence determination. The results show that individual (sex) and population-level factors (abundance) of hosts were significant predictors of local TULV dynamics. At the large geographic scale, different phylogenetic TULV clades and an overall isolation-by-distance pattern in virus sequences were detected, while at the small scale (<4 km) this depended on the study area. In combination with an overall delayed density dependence, our results highlight that frequent, localized bottleneck events for the common vole and TULV do occur and can be offset by local recolonization dynamics. View Full-Text
Keywords: rodents; hantavirus; monitoring; population dynamics; common vole; field vole; water vole; phylogeny; molecular evolution rodents; hantavirus; monitoring; population dynamics; common vole; field vole; water vole; phylogeny; molecular evolution
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MDPI and ACS Style

Schmidt, S.; Reil, D.; Jeske, K.; Drewes, S.; Rosenfeld, U.M.; Fischer, S.; Spierling, N.G.; Labutin, A.; Heckel, G.; Jacob, J.; Ulrich, R.G.; Imholt, C. Spatial and Temporal Dynamics and Molecular Evolution of Tula orthohantavirus in German Vole Populations. Viruses 2021, 13, 1132. https://doi.org/10.3390/v13061132

AMA Style

Schmidt S, Reil D, Jeske K, Drewes S, Rosenfeld UM, Fischer S, Spierling NG, Labutin A, Heckel G, Jacob J, Ulrich RG, Imholt C. Spatial and Temporal Dynamics and Molecular Evolution of Tula orthohantavirus in German Vole Populations. Viruses. 2021; 13(6):1132. https://doi.org/10.3390/v13061132

Chicago/Turabian Style

Schmidt, Sabrina, Daniela Reil, Kathrin Jeske, Stephan Drewes, Ulrike M. Rosenfeld, Stefan Fischer, Nastasja G. Spierling, Anton Labutin, Gerald Heckel, Jens Jacob, Rainer G. Ulrich, and Christian Imholt. 2021. "Spatial and Temporal Dynamics and Molecular Evolution of Tula orthohantavirus in German Vole Populations" Viruses 13, no. 6: 1132. https://doi.org/10.3390/v13061132

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