Next Article in Journal
Feasibility and Effectiveness Assessment of SARS-CoV-2 Antigenic Tests in Mass Screening of a Pediatric Population and Correlation with the Kinetics of Viral Loads
Previous Article in Journal
Effects of the Newly Isolated T4-like Phage on Transmission of Plasmid-Borne Antibiotic Resistance Genes via Generalized Transduction
Previous Article in Special Issue
Herpes Simplex Virus Type 2 Mucin-Like Glycoprotein mgG Promotes Virus Release from the Surface of Infected Cells
Review

Glycan Recognition in Human Norovirus Infections

1
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
2
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
3
Department of Laboratory Medicine, University of Gothenburg, SE 413 45 Gothenburg, Sweden
4
Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Albert Bosch
Viruses 2021, 13(10), 2066; https://doi.org/10.3390/v13102066
Received: 7 September 2021 / Revised: 7 October 2021 / Accepted: 8 October 2021 / Published: 14 October 2021
(This article belongs to the Special Issue Glycans in Viral Infection and Immunity)
Recognition of cell-surface glycans is an important step in the attachment of several viruses to susceptible host cells. The molecular basis of glycan interactions and their functional consequences are well studied for human norovirus (HuNoV), an important gastrointestinal pathogen. Histo-blood group antigens (HBGAs), a family of fucosylated carbohydrate structures that are present on the cell surface, are utilized by HuNoVs to initially bind to cells. In this review, we describe the discovery of HBGAs as genetic susceptibility factors for HuNoV infection and review biochemical and structural studies investigating HuNoV binding to different HBGA glycans. Recently, human intestinal enteroids (HIEs) were developed as a laboratory cultivation system for HuNoV. We review how the use of this novel culture system has confirmed that fucosylated HBGAs are necessary and sufficient for infection by several HuNoV strains, describe mechanisms of antibody-mediated neutralization of infection that involve blocking of HuNoV binding to HBGAs, and discuss the potential for using the HIE model to answer unresolved questions on viral interactions with HBGAs and other glycans. View Full-Text
Keywords: human noroviruses; histo-blood group antigens; glycoconjugates; human intestinal enteroids/organoids; structure; host–virus interactions human noroviruses; histo-blood group antigens; glycoconjugates; human intestinal enteroids/organoids; structure; host–virus interactions
Show Figures

Figure 1

MDPI and ACS Style

Tenge, V.R.; Hu, L.; Prasad, B.V.V.; Larson, G.; Atmar, R.L.; Estes, M.K.; Ramani, S. Glycan Recognition in Human Norovirus Infections. Viruses 2021, 13, 2066. https://doi.org/10.3390/v13102066

AMA Style

Tenge VR, Hu L, Prasad BVV, Larson G, Atmar RL, Estes MK, Ramani S. Glycan Recognition in Human Norovirus Infections. Viruses. 2021; 13(10):2066. https://doi.org/10.3390/v13102066

Chicago/Turabian Style

Tenge, Victoria R., Liya Hu, B. V.V. Prasad, Göran Larson, Robert L. Atmar, Mary K. Estes, and Sasirekha Ramani. 2021. "Glycan Recognition in Human Norovirus Infections" Viruses 13, no. 10: 2066. https://doi.org/10.3390/v13102066

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop