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Review

Natural and Experimental SARS-CoV-2 Infection in Domestic and Wild Animals

1
Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA
2
Center of Excellence for Emerging and Zoonotic Animal Diseases (CEEZAD), College of Veterinary Medicine, Kansas State University, Manhattan, KS 66502, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Herve J. A. Fleury
Viruses 2021, 13(10), 1993; https://doi.org/10.3390/v13101993
Received: 8 September 2021 / Revised: 22 September 2021 / Accepted: 24 September 2021 / Published: 4 October 2021
(This article belongs to the Special Issue HIV and SARS-CoV-2 Pathogenesis and Vaccine Development)
SARS-CoV-2 is the etiological agent responsible for the ongoing COVID-19 pandemic, which continues to spread with devastating effects on global health and socioeconomics. The susceptibility of domestic and wild animal species to infection is a critical facet of SARS-CoV-2 ecology, since reverse zoonotic spillover events resulting in SARS-CoV-2 outbreaks in animal populations could result in the establishment of new virus reservoirs. Adaptive mutations in the virus to new animal species could also complicate ongoing mitigation strategies to combat SARS-CoV-2. In addition, animal species susceptible to SARS-CoV-2 infection are essential as standardized preclinical models for the development and efficacy testing of vaccines and therapeutics. In this review, we summarize the current findings regarding the susceptibility of different domestic and wild animal species to experimental SARS-CoV-2 infection and provide detailed descriptions of the clinical disease and transmissibility in these animals. In addition, we outline the documented natural infections in animals that have occurred at the human–animal interface. A comprehensive understanding of animal susceptibility to SARS-CoV-2 is crucial to inform public health, veterinary, and agricultural systems, and to guide environmental policies. View Full-Text
Keywords: SARS-CoV-2; COVID-19; zoonotic disease; coronavirus; veterinary science; virology; animal models SARS-CoV-2; COVID-19; zoonotic disease; coronavirus; veterinary science; virology; animal models
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MDPI and ACS Style

Meekins, D.A.; Gaudreault, N.N.; Richt, J.A. Natural and Experimental SARS-CoV-2 Infection in Domestic and Wild Animals. Viruses 2021, 13, 1993. https://doi.org/10.3390/v13101993

AMA Style

Meekins DA, Gaudreault NN, Richt JA. Natural and Experimental SARS-CoV-2 Infection in Domestic and Wild Animals. Viruses. 2021; 13(10):1993. https://doi.org/10.3390/v13101993

Chicago/Turabian Style

Meekins, David A., Natasha N. Gaudreault, and Juergen A. Richt. 2021. "Natural and Experimental SARS-CoV-2 Infection in Domestic and Wild Animals" Viruses 13, no. 10: 1993. https://doi.org/10.3390/v13101993

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