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Open AccessArticle

Chronic Hepatitis B Infection Is Associated with Increased Molecular Degree of Inflammatory Perturbation in Peripheral Blood

1
Instituto Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ), Salvador 40296-710, Brazil
2
Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Salvador 41810-710, Brazil
3
Curso de Medicina, Centro Universitário Faculdade de Tecnologia e Ciências (UniFTC), Salvador 41741-590, Brazil
4
Faculdade de Medicina, Universidade Federal da Bahia, Salvador 40110-100, Brazil
5
Curso de Medicina, Universidade Salvador (UNIFACS), Laureate Universities, Salvador 41720-200, Brazil
6
Instituto Nacional de Ciencia e Tecnologia de Investigação Em Imunologia, São Paulo 05403-900, Brazil
7
Escola Bahiana de Medicina e Saúde Pública (EBMSP), Salvador 40290-000, Brazil
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Viruses 2020, 12(8), 864; https://doi.org/10.3390/v12080864
Received: 21 July 2020 / Revised: 4 August 2020 / Accepted: 5 August 2020 / Published: 7 August 2020
(This article belongs to the Special Issue Hepatitis B Virus: From Diagnostics to Treatments)
Hepatitis B virus (HBV) infection remains a major public health concern. The interaction between HBV and the host inflammatory response is an important contributing factor driving liver damage and diseases outcomes. Here, we performed a retrospective analysis employing an adapted molecular degree of perturbation (MDP) score system to assess the overall inflammatory imbalance related to persistent HBV infection. Plasma levels of several cytokines, chemokines, and other inflammatory markers were measured in Brazilian individuals diagnosed with either chronic HBV or previous HBV infection, as well as in uninfected controls between 2006 and 2007. Multidimensional analyses were used to depict and compare the overall expression profile of inflammatory markers between distinct clinical groups. Chronic HBV patients exhibited a marked inflammatory imbalance, characterized by heightened MDP scores and a distinct profile of correlation networks inputting plasma concentrations of the biomarkers, compared with either individuals with previous HBV or controls. Furthermore, in participants with chronic HBV infection, the viral loads in peripheral blood were directly proportional to overall molecular perturbation as well as to specific perturbations of interleukin (IL)-4 and interferon (IFN)-γ concentrations. These findings highlight additional nuances about systemic inflammation related to persistent HBV infection. View Full-Text
Keywords: hepatitis B virus; inflammation; molecular degree of perturbation; biomarkers; viral load hepatitis B virus; inflammation; molecular degree of perturbation; biomarkers; viral load
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Vinhaes, C.L.; Cruz, L.A.B.; Menezes, R.C.; Carmo, T.A.; Arriaga, M.B.; Queiroz, A.T.L.; Barral-Netto, M.; Andrade, B.B. Chronic Hepatitis B Infection Is Associated with Increased Molecular Degree of Inflammatory Perturbation in Peripheral Blood. Viruses 2020, 12, 864.

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