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Virus-Induced Cytoplasmic Aggregates and Inclusions are Critical Cellular Regulatory and Antiviral Factors

Department of Microbiology, Harbin Medical University, Harbin 150081, China
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Viruses 2020, 12(4), 399; https://doi.org/10.3390/v12040399
Received: 26 February 2020 / Revised: 26 March 2020 / Accepted: 1 April 2020 / Published: 4 April 2020
(This article belongs to the Section Antivirals & Vaccines)
RNA granules, aggresomes, and autophagy are key players in the immune response to viral infections. They provide countermeasures that regulate translation and proteostasis in order to rewire cell signaling, prevent viral interference, and maintain cellular homeostasis. The formation of cellular aggregates and inclusions is one of the strategies to minimize viral infections and virus-induced cell damage and to promote cellular survival. However, viruses have developed several strategies to interfere with these cellular processes in order to achieve productive replication within the host cells. A review on how these mechanisms could function as modulators of cell signaling and antiviral factors will be instrumental in refining the current scientific knowledge and proposing means whereby cellular granules and aggregates could be induced or prevented to enhance the antiviral immune response in mammalian cells. View Full-Text
Keywords: RNA granules; aggresome; autophagy; proteostasis RNA granules; aggresome; autophagy; proteostasis
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MDPI and ACS Style

Olasunkanmi, O.I.; Chen, S.; Mageto, J.; Zhong, Z. Virus-Induced Cytoplasmic Aggregates and Inclusions are Critical Cellular Regulatory and Antiviral Factors. Viruses 2020, 12, 399.

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