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Educational Material about Influenza Viruses
Comment published on 5 March 2020, see Viruses 2020, 12(3), 284.
Review

Kuru, the First Human Prion Disease

1
Laboratory of Electron Microscopy and Neuropathology, Department of Molecular Pathology and Neuropathology, Medical University Lodz, 90-419 Lodz, Poland
2
Department of Extrapyramidal Diseases, Medical University of Lodz, 90-419 Lodz, Poland
3
Department of Anthropology, Graduate Center, City University of New York, New York, NY 10016, USA
*
Author to whom correspondence should be addressed.
This paper is dedicated to late Daniel Carleton Gajdusek (1923–2008).
Viruses 2019, 11(3), 232; https://doi.org/10.3390/v11030232
Received: 1 February 2019 / Revised: 27 February 2019 / Accepted: 1 March 2019 / Published: 7 March 2019
(This article belongs to the Section Prions)
Kuru, the first human prion disease was transmitted to chimpanzees by D. Carleton Gajdusek (1923–2008). In this review, we summarize the history of this seminal discovery, its anthropological background, epidemiology, clinical picture, neuropathology, and molecular genetics. We provide descriptions of electron microscopy and confocal microscopy of kuru amyloid plaques retrieved from a paraffin-embedded block of an old kuru case, named Kupenota. The discovery of kuru opened new vistas of human medicine and was pivotal in the subsequent transmission of Creutzfeldt–Jakob disease, as well as the relevance that bovine spongiform encephalopathy had for transmission to humans. The transmission of kuru was one of the greatest contributions to biomedical sciences of the 20th century. View Full-Text
Keywords: Kuru; prion diseases; neuropathology; Carleton Gajdusek Kuru; prion diseases; neuropathology; Carleton Gajdusek
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MDPI and ACS Style

Liberski, P.P.; Gajos, A.; Sikorska, B.; Lindenbaum, S. Kuru, the First Human Prion Disease. Viruses 2019, 11, 232. https://doi.org/10.3390/v11030232

AMA Style

Liberski PP, Gajos A, Sikorska B, Lindenbaum S. Kuru, the First Human Prion Disease. Viruses. 2019; 11(3):232. https://doi.org/10.3390/v11030232

Chicago/Turabian Style

Liberski, Paweł P., Agata Gajos, Beata Sikorska, and Shirley Lindenbaum. 2019. "Kuru, the First Human Prion Disease" Viruses 11, no. 3: 232. https://doi.org/10.3390/v11030232

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